Het-PDB Navi2 (PDB: 1DF1)

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Ligands
Code	Name	Link
ZN	Zinc ion	PoSSuM
HEM	Protoporphyrin ix containing Fe	PoSSuM
H4B	5,6,7,8-tetrahydrobiopterin	PoSSuM
ITU	Ethylisothiourea	PoSSuM

Non-standard Residues
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Glycosylation
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Download interaction data: 1DF1

Code :

1DF1 PDBj RCSB PDB PDBe

Header :

OXIDOREDUCTASE

Title :

MURINE INOSOXY DIMER WITH ISOTHIOUREA BOUND IN THE ACTIVE SITE

Release Data :

1999-12-08

Compound :

mol_id	molecule	chains	synonym
1	NITRIC OXIDE SYNTHASE	A,B	NOS
	ec: 1.14.13.39

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Mus musculus (taxid:10090)	House mouse	Escherichia coli (taxid:562)
	cell: MACROPHAGE expression_system_vector: PCWORI

Authors :

Crane, B.R., Rosenfeld, R.J., Arvai, A.S., Ghosh, D.K., Ghosh, S., Tainer, J.A., Stuehr, D.J., Getzoff, E.D.

Keywords :

NITRIC OXIDE L-ARGININE MONOOXYGENASE, NOS, HEME, ISOTHIOUREA, INOS, OXIDOREDUCTASE

Exp. method :

X-RAY DIFFRACTION ( 2.35 Å )

Citation :

N-terminal domain swapping and metal ion binding in nitric oxide synthase dimerization.

Crane, B.R.,Rosenfeld, R.J.,Arvai, A.S. et al.
(1999) EMBO J. 18 : 6271 - 6281

Structure of Nitric Oxide Synthase Oxygenase Dimer with Pterin and Substrate

Crane, B.R.,Arvai, A.S.,Ghosh, D.K. et al.
(1998) Science 279 : 2121 - 2126

Chain :

A, B

UniProt :

P29477 (NOS2_MOUSE)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
2 L-arginine + 3 NADPH + 4 O2 + H(+) = 2 L-citrulline + 2 nitric oxide + 3 NADP(+) + 4 H2O	1.14.13.39	UniProtKB:P35228
	left-to-right	UniProtKB:P35228
Cofactor:	Evidence:	Note:
heme b	ECO:0000269 \| PubMed:10562539 ECO:0000269 \| PubMed:10769116 ECO:0000269 \| PubMed:12437348 ECO:0000269 \| PubMed:12464241 ECO:0000269 \| PubMed:9516116	-
FAD	ECO:0000250 \| UniProtKB:P29476	Binds 1 FAD.
FMN	ECO:0000250 \| UniProtKB:P35228	Binds 1 FMN.
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin	ECO:0000269 \| PubMed:10562539 ECO:0000269 \| PubMed:10769116 ECO:0000269 \| PubMed:11669619 ECO:0000269 \| PubMed:12437348 ECO:0000269 \| PubMed:12464241 ECO:0000269 \| PubMed:9516116	Tetrahydrobiopterin (BH4). May stabilize the dimeric form of the enzyme.

PDB ID: 1DF1