Brand  (β version)

PDB ID: 1DF1

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Ligands
Code Name Style Show Link
ZN Zinc ion PoSSuM
HEM Protoporphyrin ix containing Fe PoSSuM
H4B 5,6,7,8-tetrahydrobiopterin PoSSuM
ITU Ethylisothiourea PoSSuM
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Structure summary

Code : 1DF1   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : MURINE INOSOXY DIMER WITH ISOTHIOUREA BOUND IN THE ACTIVE SITE
Release Data : 1999-12-08
Compound :
mol_id molecule chains synonym
1 NITRIC OXIDE SYNTHASE A,B NOS
ec: 1.14.13.39
Source :
mol_id organism_scientific organism_common expression_system
1 Mus musculus  (taxid:10090) House mouse Escherichia coli  (taxid:562)
cell: MACROPHAGE
expression_system_vector: PCWORI
Authors : Crane, B.R., Rosenfeld, R.J., Arvai, A.S., Ghosh, D.K., Ghosh, S., Tainer, J.A., Stuehr, D.J., Getzoff, E.D.
Keywords : NITRIC OXIDE L-ARGININE MONOOXYGENASE, NOS, HEME, ISOTHIOUREA, INOS, OXIDOREDUCTASE
Exp. method : X-RAY DIFFRACTION ( 2.35 Å )
Citation :

N-terminal domain swapping and metal ion binding in nitric oxide synthase dimerization.

Crane, B.R.,Rosenfeld, R.J.,Arvai, A.S.  et al.
(1999)  EMBO J.  18 : 6271 - 6281

PubMed: 10562539
DOI: 10.1093/emboj/18.22.6271

Structure of Nitric Oxide Synthase Oxygenase Dimer with Pterin and Substrate

Crane, B.R.,Arvai, A.S.,Ghosh, D.K.  et al.
(1998)  Science  279 : 2121 - 2126

DOI: 10.1126/science.279.5359.2121

Reaction

Chain : A, B
UniProt : P29477 (NOS2_MOUSE)
Reaction: EC: Evidence:
Physiological Direction:
H(+) + 2 L-arginine + 3 NADPH + 4 O2 = 4 H2O + 2 L-citrulline + 3 NADP(+) + 2 nitric oxide 1.14.13.39 UniProtKB:P35228
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