Brand  (β version)

PDB ID: 1DCT

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Ligands
Code Name Style Show Link
CA Calcium ion PoSSuM
Non-standard Residues
Code Name Show
C49 4-thio,5-fluoro,5-methyl-2'-deoxy-cytidine-5'-monophosphate
5CM 5-methyl-2'-deoxy-cytidine-5'-monophosphate
Glycosylation
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Modification
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Structure summary

Code : 1DCT   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE/DNA
Title : DNA (CYTOSINE-5) METHYLASE FROM HAEIII COVALENTLY BOUND TO DNA
Release Data : 1995-09-15
Compound :
mol_id molecule chains
1 DNA (5'-D(*AP*CP*CP*AP*GP*CP*AP*GP*GP*(C49)P*CP*AP*CP*CP*AP*GP*TP*G)-3') F,G
mol_id molecule chains
2 DNA (5'-D(*TP*CP*AP*CP*TP*GP*GP*TP*GP*GP*(C5M)P*CP*TP*GP*CP*TP*GP*G)-3') M,N
mol_id molecule chains synonym
3 PROTEIN (MODIFICATION METHYLASE HAEIII) A,B CYTOSINE-SPECIFIC METHYLTRANSFERASE, HAEIII, M.HAEIII
ec: 2.1.1.73
Source :
mol_id organism_scientific
1
synthetic: yes
mol_id organism_scientific
2
synthetic: yes
mol_id organism_scientific
3 Haemophilus influenzae biotype aegyptius  (taxid:725)
strain: biotype aegyptius
Authors : Reinisch, K.M., Chen, L., Verdine, G.L., Lipscomb, W.N.
Keywords : ENZYME, CYTOSINE METHYLASE, TRANSFERASE-DNA COMPLEX
Exp. method : X-RAY DIFFRACTION ( 2.800 Å )
Citation :

The crystal structure of HaeIII methyltransferase convalently complexed to DNA: an extrahelical cytosine and rearranged base pairing.

Reinisch, K.M.,Chen, L.,Verdine, G.L.  et al.
(1995)  Cell(Cambridge,Mass.)  82 : 143 - 153

PubMed: 7606780
DOI: 10.1016/0092-8674(95)90060-8

Crystallization and Prelimanary Crystallographic Analysis of a DNA (Cytosine-5) -Methyltransferase from Haemophilus Aegyptius Bound Covalently to DNA

Reinisch, K.M.,Chen, L.,Verdine, G.L.  et al.
(1994)  J.Mol.Biol.  238 : 626 - 629

Reaction

Chain : A, B
UniProt : P20589 (MTH3_HAEAE)
Reaction: EC: Evidence:
Physiological Direction:
a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine = a 5- methyl-2'-deoxycytidine in DNA + H(+) + S-adenosyl-L-homocysteine 2.1.1.37 PROSITE-ProRule:PRU10018, PubMed:1932026
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