Brand  (β version)

PDB ID: 1DAN

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Ligands
Code Name Style Show Link
0Z6 D-phenylalanyl-N-[(2s,3s)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-phenylalaninamide PoSSuM
CA Calcium ion PoSSuM
CAC Cacodylate ion PoSSuM
CL Chloride ion PoSSuM
Non-standard Residues
Code Name Show
CGU Gamma-carboxy-glutamic acid
Glycosylation
Code Name Emphasize
BGC Beta-D-glucopyranose
FUC Alpha-L-fucopyranose
Modification
Code Name Show

Structure summary

Code : 1DAN   PDBj   RCSB PDB   PDBe
Header : HYDROLASE/HYDROLASE INHIBITOR
Title : Complex of active site inhibited human blood coagulation factor VIIA with human recombinant soluble tissue factor
Release Data : 1997-09-04
Compound :
mol_id molecule chains
1 BLOOD COAGULATION FACTOR VIIA light chain L
ec: 3.4.21.21
mol_id molecule chains
2 BLOOD COAGULATION FACTOR VIIA heavy chain H
ec: 3.4.21.21
mol_id molecule chains
3 SOLUBLE TISSUE FACTOR T
mol_id molecule chains
4 SOLUBLE TISSUE FACTOR U
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Mesocricetus auratus  (taxid:10036)
cell_line: BABY HAMSTER KIDNEY CELLS
organ: BLOOD
expression_system_common: Golden hamster
expression_system_cell_line: BHK CELLS
mol_id organism_scientific organism_common expression_system
2 Homo sapiens  (taxid:9606) Human Mesocricetus auratus  (taxid:10036)
cell_line: BABY HAMSTER KIDNEY CELLS
organ: BLOOD
expression_system_common: Golden hamster
expression_system_cell_line: BHK CELLS
mol_id organism_scientific organism_common expression_system
3 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
cell_line: BABY HAMSTER KIDNEY CELLS
organ: BLOOD
mol_id organism_scientific organism_common expression_system
4 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
cell_line: BABY HAMSTER KIDNEY CELLS
organ: BLOOD
Authors : Banner, D.W.
Keywords : BLOOD COAGULATION, SERINE PROTEASE, CO-FACTOR, RECEPTOR ENZYME, GLA, EGF, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
Exp. method : X-RAY DIFFRACTION ( 2.00 Å )
Citation :

The crystal structure of the complex of blood coagulation factor VIIa with soluble tissue factor.

Banner, D.W.,D'Arcy, A.,Chene, C.  et al.
(1996)  Nature  380 : 41 - 46

PubMed: 8598903
DOI: 10.1038/380041a0

Reaction

Chain : H
UniProt : P08709 (FA7_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
Selective cleavage of Arg-|-Ile bond in factor X to form factor Xa. 3.4.21.21 -
-
Chain : U
UniProt : P13726 (TF_HUMAN)
Reaction : -