Brand  (β version)

PDB ID: 1D7W

Hetero Atom Contents

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Code Name Style Show Link
BR Bromide ion PoSSuM
SO4 Sulfate ion PoSSuM
CYN Cyanide ion PoSSuM
ACT Acetate ion PoSSuM
HEM Protoporphyrin ix containing Fe PoSSuM
CA Calcium ion PoSSuM

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Non-standard Residues
Code Name Show
CSO S-hydroxycysteine
Glycosylation
Code Name Emphasize
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose
BMA Beta-D-mannopyranose
MAN Alpha-D-mannopyranose
FUC Alpha-L-fucopyranose
Modification
Code Name Show

Structure summary

Code : 1D7W   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : CRYSTAL STRUCTURE OF HUMAN MYELOPEROXIDASE ISOFORM C COMPLEXED WITH CYANIDE AND BROMIDE AT PH 4.0
Release Data : 2001-12-12
Compound :
mol_id molecule chains
1 MYELOPEROXIDASE A,B
ec: 1.11.1.7
fragment: LIGHT CHAIN
mol_id molecule chains
2 MYELOPEROXIDASE C,D
ec: 1.11.1.7
fragment: HEAVY CHAIN
Source :
mol_id organism_scientific organism_common
1 Homo sapiens  (taxid:9606) Human
tissue: BLOOD
cell: NEUTROPHIL
mol_id organism_scientific organism_common
2 Homo sapiens  (taxid:9606) Human
tissue: BLOOD
cell: NEUTROPHIL
Authors : Fiedler, T.J., Fenna, R.E.
Keywords : HEME-PROTEIN, PEROXIDASE, OXIDOREDUCTASE, PEROXIDASE-CYANIDE-BROMIDE COMPLEX
Exp. method : X-RAY DIFFRACTION ( 1.90 Å )
Citation :

Human myeloperoxidase: structure of a cyanide complex and its interaction with bromide and thiocyanate substrates at 1.9 A resolution.

Blair-Johnson, M.,Fiedler, T.,Fenna, R.
(2001)  Biochemistry  40 : 13990 - 13997

PubMed: 11705390
DOI: 10.1021/bi0111808

Structure of the Green Heme in Myeloperoxidase

Fenna, R.,Zeng, J.,Davey, C.
(1995)  Arch.Biochem.Biophys.  316 : 653

DOI: 10.1006/abbi.1995.1086

2.3 Angstrom Resolution X-Ray Crystal Structure of the Bisubstrate Analogue Inhibitor Salicylhydroxamic Acid Bound to Human Myeloperoxidase: A Model for a Prereaction Complex with Hydrogen Peroxide

Davey, C.A.,Fenna, R.E.
(1996)  Biochemistry  35 : 10967

DOI: 10.1021/bi960577m

X-Ray Crystal Structure of Canine Myeloperoxidase at 3 Angstrom Resolution

Zeng, J.,Fenna, R.E.
(1992)  J.Mol.Biol.  226 : 185

Site-Directed Mutagenesis of Human Myeloperoxidase: Further Identification of Residues Involved in Catalytic Activity and Heme Interaction

Jacquet, A.,Garcia-Quintana, L.,Deleersnyder, V.  et al.
(1994)  Biochem.Biophys.Res.Commun.  202 : 73

DOI: 10.1006/bbrc.1994.1895

Reaction

Chain : C, D
UniProt : P05164 (PERM_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
chloride + H2O2 + H(+) = hypochlorous acid + H2O 1.11.2.2 PubMed:16125131, PubMed:17074761, PubMed:17438335, PubMed:19608745, PubMed:21880720, PubMed:22131345, PubMed:22902565, PubMed:24194519, PubMed:9359420, PubMed:9922160
left-to-right PubMed:16125131, PubMed:17074761, PubMed:17438335, PubMed:19608745, PubMed:21880720, PubMed:22131345, PubMed:22902565, PubMed:24194519
thiocyanate + H2O2 + H(+) = hypothiocyanous acid + H2O - PubMed:16125131, PubMed:6295491
left-to-right
bromide + H2O2 = hypobromite + H2O - PubMed:16125131, PubMed:17438335
left-to-right
iodide + H2O2 = hypoiodite + H2O - PubMed:1318692
left-to-right
Cofactor: Evidence: Note:
Ca(2+) ECO:0000269 | PubMed:10766826
ECO:0000269 | PubMed:11705390
ECO:0000269 | PubMed:19608745
ECO:0000269 | PubMed:21880720
ECO:0000269 | PubMed:22352991
ECO:0000269 | PubMed:28348079
ECO:0000269 | PubMed:28808028
ECO:0000269 | PubMed:29306874
ECO:0000269 | PubMed:36150500
ECO:0000269 | PubMed:40963017
ECO:0000269 | PubMed:7840679
Binds 1 Ca(2+) ion per monomer.
heme b ECO:0000269 | PubMed:17438335
ECO:0000269 | PubMed:19608745
ECO:0000269 | PubMed:21880720
ECO:0000269 | PubMed:22352991
ECO:0000269 | PubMed:23843990
ECO:0000269 | PubMed:28348079
ECO:0000269 | PubMed:40963017
ECO:0000269 | PubMed:7840679
Binds 1 heme b (iron(II)-protoporphyrin IX) group covalently per monomer.