Brand  (β version)

PDB ID: 1D6Y

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Color scheme of protein:

Ligands
Code Name Style Show Link
CA Calcium ion PoSSuM
CU Copper (II) ion PoSSuM
GOL Glycerol PoSSuM
HY1 Phenylacetaldehyde PoSSuM
NO Nitric oxide PoSSuM
PEA 2-phenylethylamine PoSSuM
Non-standard Residues
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TYQ 3-amino-6-hydroxy-tyrosine
Glycosylation
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Structure summary

Code : 1D6Y   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : CRYSTAL STRUCTURE OF E. COLI COPPER-CONTAINING AMINE OXIDASE ANAEROBICALLY REDUCED WITH BETA-PHENYLETHYLAMINE AND COMPLEXED WITH NITRIC OXIDE.
Release Data : 2000-02-02
Compound :
mol_id molecule chains
1 COPPER AMINE OXIDASE A,B
ec: 1.4.3.6
Source :
mol_id organism_scientific expression_system
1 Escherichia coli  (taxid:562) Escherichia coli  (taxid:562)
Authors : Wilmot, C.M., Hajdu, J., McPherson, M.J., Knowles, P.F., Phillips, S.E.V.
Keywords : REACTION INTERMEDIATE MIMIC, OXIDOREDUCTASE
Exp. method : X-RAY DIFFRACTION ( 2.4 Å )
Citation :

Visualization of dioxygen bound to copper during enzyme catalysis.

Wilmot, C.M.,Hajdu, J.,McPherson, M.J.  et al.
(1999)  Science  286 : 1724 - 1728

PubMed: 10576737
DOI: 10.1126/science.286.5445.1724

The Active Site Base Controls Cofactor Reactivity in Escherichia coli Amine Oxidase: X-ray Crystallographic Studies with Mutational Variants.

Murray, J.M.,Saysell, C.G.,Wilmot, C.M.  et al.
(1999)  Biochemistry  38 : 8217 - 8227

DOI: 10.1021/bi9900469

Catalytic Mechanism of the Quinoenzyme Amine Oxidase from Escherichia coli: Exploring the Reductive Half-Reaction.

Wilmot, C.M.,Murray, J.M.,Alton, G.  et al.
(1997)  Biochemistry  36 : 1608 - 1620

DOI: 10.1021/bi962205j

Crystal Structure of a Quinoenzyme: Copper Amine Oxidase of Escherichia coli at 2 Angstroms Resolution.

Parsons, M.R.,Convery, M.A.,Wilmot, C.M.  et al.
(1995)  Structure  3 : 1171 - 1184

Reaction

Chain : A, B
UniProt : P46883 (AMO_ECOLI)
Reaction: EC: Evidence:
Physiological Direction:
an aliphatic amine + H2O + O2 = an aldehyde + H2O2 + NH4(+) 1.4.3.21 PubMed:10387067, PubMed:10576737, PubMed:9048544
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2-phenylethylamine + H2O + O2 = 2-phenylacetaldehyde + H2O2 + NH4(+) 1.4.3.21 PubMed:10576737
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