Het-PDB Navi2 (PDB: 1D6W)

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Ligands
Code	Name		Style	Show	Link
00R	(5s)-N-[trans-4-(2-amino-1h-imidazol-5-yl)cyclohexyl]-1,3-dioxo-2-[2-(phenylsulfonyl)ethyl]-2,3,5,8-tetrahydro-1h-[1,2,4]triazolo[1,2-a]pyridazine-5-carboxamide				PoSSuM
NA	Sodium ion				PoSSuM

Non-standard Residues
Code	Name	Show
TYS	O-sulfo-L-tyrosine

Glycosylation
Code	Name	Emphasize

Modification
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Download interaction data: 1D6W

Code :

1D6W PDBj RCSB PDB PDBe

Header :

HYDROLASE/HYDROLASE INHIBITOR

Title :

STRUCTURE OF THROMBIN COMPLEXED WITH SELECTIVE NON-ELECTROPHILIC INHIBITORS HAVING CYCLOHEXYL MOIETIES AT P1

Release Data :

2000-10-25

Compound :

mol_id	molecule	chains
1	THROMBIN	A
	ec: 3.4.21.5

mol_id	molecule	chains
2	DECAPEPTIDE INHIBITOR	I

Source :

mol_id	organism_scientific	organism_common
1	Homo sapiens (taxid:9606)	Human

mol_id	organism_scientific
2	Hirudo medicinalis (taxid:6421)
	synthetic: yes other_details: THIS SEQUENCE WAS CHEMICALLY SYNTHESIZED

Authors :

Mochalkin, I., Tulinsky, A.

Keywords :

HYDROLASE, THROMBIN, THROMBIN INHIBITOR, HYDROLASE-HYDROLASE INHIBITOR COMPLEX

Exp. method :

X-RAY DIFFRACTION ( 2.0 Å )

Citation :

Structure of thrombin complexed with selective non-electrophilic inhibitors having cyclohexyl moieties at P1.

Krishnan, R.,Mochalkin, I.,Arni, R. et al.
(2000) Acta Crystallogr.,Sect.D 56 : 294 - 303

Chain :

UniProt :

P00734 (THRB_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
Selective cleavage of Arg-\|-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B.	3.4.21.5	-
	-	-

PDB ID: 1D6W