Brand  (β version)

color scheme of protein:

hetatm:

x
information
centroid:
interaction residue:

chain:

Ligands
Code Name Link
COA Coenzyme a
SO4 Sulfate ion
Modified Residues
Code Name Link
CSD 3-sulfinoalanine
Code : 1D6H
Header : TRANSFERASE
Title : CHALONE SYNTHASE (N336A MUTANT COMPLEXED WITH COA)
Release Data : 2000-02-03
Compound :
mol_id molecule chains
1 CHALCONE SYNTHASE A
ec: 2.3.1.74
mutation: N336A
Source :
mol_id organism_scientific expression_system
1 Medicago sativa  (taxid:3879) Escherichia coli  (taxid:562)
expression_system_vector: PHIS8 (VARIANT OF PET-28B)
Authors : Jez, J.M., Ferrer, J.L., Bowman, M.E., Dixon, R.A., Noel, J.P.
Keywords : POLYPETIDE SYNTHASE, FLAVONOID BIOSYNTHESIS, MALONYL-COA DECARBOXYLATION, SITE-DIRECTED MUTANT, TRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 2.15 Å )
Citation :

Dissection of malonyl-coenzyme A decarboxylation from polyketide formation in the reaction mechanism of a plant polyketide synthase.

Jez, J.M.,Ferrer, J.L.,Bowman, M.E.  et al.
(2000)  Biochemistry  39 : 890 - 902

PubMed: 10653632
DOI: 10.1021/bi991489f

Chain : A
UniProt : P30074 (CHS2_MEDSA)
Reaction : 3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + naringenin chalcone + 3 CO(2).