Brand  (β version)

PDB ID: 1D5R

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Ligands
Code Name Style Show Link
TLA L(+)-tartaric acid PoSSuM
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Structure summary

Code : 1D5R   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : Crystal Structure of the PTEN Tumor Suppressor
Release Data : 1999-11-04
Compound :
mol_id molecule chains
1 PHOSPHOINOSITIDE PHOSPHATASE PTEN A
ec: 3.1.3.48
fragment: RESIDUES 7-353
mutation: RESIDUES 286-309 ARE REPLACED BY VAL
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Trichoplusia ni  (taxid:7111)
expression_system_common: Cabbage looper
expression_system_cell_line: HIGH FIVE
expression_system_vector: BACULOVIRUS
expression_system_plasmid: PVL1393
Authors : Lee, J.O., Yang, H., Georgescu, M.-M., Di Cristofano, A., Pavletich, N.P.
Keywords : C2 DOMAIN, PHOSPHOTIDYLINOSITOL, PHOSPHATASE, HYDROLASE
Exp. method : X-RAY DIFFRACTION ( 2.1 Å )
Citation :

Crystal structure of the PTEN tumor suppressor: implications for its phosphoinositide phosphatase activity and membrane association.

Lee, J.O.,Yang, H.,Georgescu, M.M.  et al.
(1999)  Cell(Cambridge,Mass.)  99 : 323 - 334

PubMed: 10555148
DOI: 10.1016/S0092-8674(00)81663-3

Reaction

Chain : A
UniProt : P60484 (PTEN_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5- trisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo- inositol-4,5-bisphosphate) + phosphate 3.1.3.67 PubMed:16824732, PubMed:9811831
left-to-right PubMed:16824732
H2O + O-phospho-L-seryl-[protein] = L-seryl-[protein] + phosphate 3.1.3.16 PubMed:9256433
left-to-right
H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate 3.1.3.16 PubMed:9256433
left-to-right
H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate 3.1.3.48 PubMed:9187108, PubMed:9256433
left-to-right PubMed:9256433
1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5- trisphosphate) + H2O = 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo- inositol-4,5-bisphosphate) + phosphate - PubMed:16824732, PubMed:9593664
left-to-right PubMed:16824732
1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol- 3,4,5-trisphosphate) + H2O = 1,2-dihexadecanoyl-sn-glycero-3-phospho- (1D-myo-inositol-4,5-bisphosphate) + phosphate - PubMed:16824732, PubMed:9593664
left-to-right PubMed:16824732
1D-myo-inositol 1,3,4,5,6-pentakisphosphate + H2O = 1D-myo- inositol 1,4,5,6-tetrakisphosphate + phosphate - PubMed:11418101
left-to-right
1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = 1D-myo- inositol 1,4,5-trisphosphate + phosphate - PubMed:9593664
left-to-right