Brand  (β version)

PDB ID: 1D5M

Hetero Atom Contents

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Ligands
Code Name Style Show Link
Non-standard Residues
Code Name Show
ALC 2-amino-3-cyclohexyl-propionic acid
CY1 Acetamidomethylcysteine
Glycosylation
Code Name Emphasize
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose
Modification
Code Name Show
ACE Acetyl group
NH2 Amino group

Structure summary

Code : 1D5M   PDBj   RCSB PDB   PDBe
Header : IMMUNE SYSTEM/PEPTIDE INHIBITOR
Title : X-RAY CRYSTAL STRUCTURE OF HLA-DR4 COMPLEXED WITH PEPTIDE AND SEB
Release Data : 2000-06-28
Compound :
mol_id molecule chains synonym
1 HLA CLASS II HISTOCOMPATIBILITY ANTIGEN A HLA-DR4
fragment: DR ALPHA CHAIN, EXTRACELLULAR DOMAIN
mol_id molecule chains synonym
2 HLA CLASS II HISTOCOMPATIBILITY ANTIGEN B HLA-DR4
fragment: DR-4 BETA CHAIN, EXTRACELLULAR DOMAIN
mol_id molecule chains synonym
3 ENTEROTOXIN TYPE B C SEB, SUPERANTIGEN
mol_id molecule chains
4 INHIBITOR D
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Drosophila melanogaster  (taxid:7227)
expression_system_common: Fruit fly
mol_id organism_scientific organism_common expression_system
2 Homo sapiens  (taxid:9606) Human Drosophila melanogaster  (taxid:7227)
expression_system_common: Fruit fly
mol_id organism_scientific
3 Staphylococcus aureus  (taxid:1280)
mol_id organism_scientific
4 Synthetic construct  (taxid:32630)
synthetic: yes
Authors : Swain, A.L., Crowther, R., Kammlott, U.
Keywords : MHC CLASS II-SUPERANTIGEN COMPLEX, IMMUNE SYSTEM-PEPTIDE INHIBITOR COMPLEX, PEPTIDOMIMETIC INHIBITOR
Exp. method : X-RAY DIFFRACTION ( 2.00 Å )
Citation :

Peptide and peptide mimetic inhibitors of antigen presentation by HLA-DR class II MHC molecules. Design, structure-activity relationships, and X-ray crystal structures.

Bolin, D.R.,Swain, A.L.,Sarabu, R.  et al.
(2000)  J.Med.Chem.  43 : 2135 - 2148

PubMed: 10841792
DOI: 10.1021/jm000034h

Reaction

Chain : A
UniProt : P01903 (DRA_HUMAN)
Reaction : -
Chain : B
UniProt : P13760 (DRB1_HUMAN)
Reaction : -
Chain : C
UniProt : P01552 (ETXB_STAAU)
Reaction : -