Brand  (β version)

PDB ID: 1D3H

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Ligands
Code Name Style Show Link
A26 (2z)-2-cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]but-2-enamide PoSSuM
ACT Acetate ion PoSSuM
FMN Flavin mononucleotide PoSSuM
ORO Orotic acid PoSSuM
SO4 Sulfate ion PoSSuM
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Structure summary

Code : 1D3H   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : HUMAN DIHYDROOROTATE DEHYDROGENASE COMPLEXED WITH ANTIPROLIFERATIVE AGENT A771726
Release Data : 2000-08-13
Compound :
mol_id molecule chains
1 DIHYDROOROTATE DEHYDROGENASE A
ec: 1.3.3.1
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
expression_system_plasmid: PET19B
Authors : Liu, S., Neidhardt, E.A., Grossman, T.H., Ocain, T., Clardy, J.
Keywords : ALPHA-BETA BARREL, MEMBRANE BINDING MOTIF, OXIDOREDUCTASE
Exp. method : X-RAY DIFFRACTION ( 1.80 Å )
Citation :

Structures of human dihydroorotate dehydrogenase in complex with antiproliferative agents.

Liu, S.,Neidhardt, E.A.,Grossman, T.H.  et al.
(2000)  Structure Fold.Des.  8 : 25 - 33

PubMed: 10673429
DOI: 10.1016/S0969-2126(00)00077-0

Reaction

Chain : A
UniProt : Q02127 (PYRD_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
(S)-dihydroorotate + a quinone = orotate + a quinol 1.3.5.2 PubMed:8925840
-
Cofactor: Evidence: Note:
FMN ECO:0000269 | PubMed:10673429
Binds 1 FMN per subunit.