Brand  (β version)

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Ligands
Code Name Style Show Link
CA Calcium ion
BR Bromide ion
SO4 Sulfate ion
HEM Protoporphyrin ix containing Fe
ACT Acetate ion
Non-standard Residues
Code Name Show
CSO S-hydroxycysteine
Glycosylation
Code Name Emphasize
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose
BMA Beta-D-mannopyranose
MAN Alpha-D-mannopyranose
FUC Alpha-L-fucopyranose
Modification
Code Name Show
Code : 1D2V   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : CRYSTAL STRUCTURE OF BROMIDE-BOUND HUMAN MYELOPEROXIDASE ISOFORM C AT PH 5.5
Release Data : 2000-04-24
Compound :
mol_id molecule chains
1 MYELOPEROXIDASE A,B
ec: 1.11.1.7
fragment: LIGHT CHAIN
mol_id molecule chains
2 MYELOPEROXIDASE C,D
ec: 1.11.1.7
fragment: HEAVY CHAIN
Source :
mol_id organism_scientific organism_common
1 Homo sapiens  (taxid:9606) Human
tissue: BLOOD
cell: NEUTROPHIL
mol_id organism_scientific organism_common
2 Homo sapiens  (taxid:9606) Human
tissue: BLOOD
cell: NEUTROPHIL
Authors : Fiedler, T.J., Davey, C.A., Fenna, R.E.
Keywords : HEME-PROTEIN, PEROXIDASE, OXIDOREDUCTASE, PEROXIDASE-BROMIDE COMPLEX
Exp. method : X-RAY DIFFRACTION ( 1.75 Å )
Citation :

X-ray crystal structure and characterization of halide-binding sites of human myeloperoxidase at 1.8 A resolution.

Fiedler, T.J.,Davey, C.A.,Fenna, R.E.
(2000)  J.Biol.Chem.  275 : 11964 - 11971

PubMed: 10766826
DOI: 10.1074/jbc.275.16.11964

Structure of the Green Heme in Myeloperoxidase

Fenna, R.,Zeng, J.,Davey, C.
(1995)  Arch.Biochem.Biophys.  316 : 653

DOI: 10.1006/abbi.1995.1086

2.3 Angstrom Resolution X-Ray Crystal Structure of the Bisubstrate Analogue Inhibitor Salicylhydroxamic Acid Bound to Human Myeloperoxidase: A Model for a Prereaction Complex with Hydrogen Peroxide

Davey, C.A.,Fenna, R.E.
(1996)  Biochemistry  35 : 10967

DOI: 10.1021/bi960577m

X-Ray Crystal Structure of Canine Myeloperoxidase at 3 Angstrom Resolution

Zeng, J.,Fenna, R.E.
(1992)  J.Mol.Biol.  226 : 185

Site-Directed Mutagenesis of Human Myeloperoxidase: Further Identification of Residues Involved in Catalytic Activity and Heme Interaction

Jacquet, A.,Garcia-Quintana, L.,Deleersnyder, V.  et al.
(1994)  Biochem.Biophys.Res.Commun.  202 : 73

DOI: 10.1006/bbrc.1994.1895

Chain : C, D
UniProt : P05164 (PERM_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
chloride + H(+) + H2O2 = H2O + hypochlorous acid 1.11.2.2 PubMed:9922160
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