Brand  (β version)

PDB ID: 1D22

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Ligands
Code Name Style Show Link
NGU U-58872, hydroxy derivative of nogalamycin PoSSuM
Non-standard Residues
Code Name Show
5CM 5-methyl-2'-deoxy-cytidine-5'-monophosphate
AS 2-deoxy-adenosine -5'-thio-monophosphate
Glycosylation
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Structure summary

Code : 1D22   PDBj   RCSB PDB   PDBe
Header : DNA
Title : BINDING OF THE ANTITUMOR DRUG NOGALAMYCIN AND ITS DERIVATIVES TO DNA: STRUCTURAL COMPARISON
Release Data : 1991-07-15
Compound :
mol_id molecule chains
1 DNA (5'-D(*(5CM)P*GP*TP*(AS)P*(5CM)P*G)-3') A,B
Source :
mol_id organism_scientific
1
synthetic: yes
Authors : Gao, Y.-G., Liaw, Y.-C., Robinson, H., Wang, A.H.-J.
Keywords : RIGHT HANDED DNA, DOUBLE HELIX, COMPLEXED WITH DRUG, MODIFIED, DNA
Exp. method : X-RAY DIFFRACTION ( 1.800 Å )
Citation :

Binding of the antitumor drug nogalamycin and its derivatives to DNA: structural comparison.

Gao, Y.G.,Liaw, Y.C.,Robinson, H.  et al.
(1990)  Biochemistry  29 : 10307 - 10316

PubMed: 2261474
DOI: 10.1021/bi00497a004

NMR Studies on the Binding of Antitumor Drug Nogalamycin to DNA Hexamer d(CGTACG)

Robinson, H.,Liaw, Y.-C.,Van Der Marel, G.A.  et al.
(1990)  Nucleic Acids Res.  18 : 4851 - 4858

Antitumor Drug Nogalamycin Binds DNA in Both Grooves Simultaneously: Molecular Structure of Nogalamycin-DNA Complex

Liaw, Y.-C.,Gao, Y.-G.,Robinson, H.  et al.
(1989)  Biochemistry  28 : 9913 - 9918