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Ligands
Code Name Style Show Link
ACT Acetate ion
ATQ 2-aminothiazoline
CAD Cacodylic acid
GOL Glycerol
H4B 5,6,7,8-tetrahydrobiopterin
HEM Protoporphyrin ix containing Fe
ZN Zinc ion
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Code : 1D1W   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : BOVINE ENDOTHELIAL NITRIC OXIDE SYNTHASE HEME DOMAIN COMPLEXED WITH 2-AMINOTHIAZOLINE (H4B BOUND)
Release Data : 2000-10-25
Compound :
mol_id molecule chains synonym
1 NITRIC OXIDE SYNTHASE A,B NOS, ENOS
ec: 1.14.13.39
fragment: HEME DOMAIN
Source :
mol_id organism_scientific organism_common expression_system
1 Bos taurus  (taxid:9913) Cattle Escherichia coli  (taxid:562)
cell: ENDOTHELIAL CELLS
Authors : Li, H., Raman, C.S., Martasek, P., Kral, V., Masters, B.S.S., Poulos, T.L.
Keywords : ALPHA-BETA FOLD, OXIDOREDUCTASE
Exp. method : X-RAY DIFFRACTION ( 2.00 Å )
Citation :

Mapping the active site polarity in structures of endothelial nitric oxide synthase heme domain complexed with isothioureas.

Li, H.,Raman, C.S.,Martasek, P.  et al.
(2000)  J.Inorg.Biochem.  81 : 133 - 139

PubMed: 11051558
DOI: 10.1016/S0162-0134(00)00099-4

Crystal Structure of Constitutive Endothelial Nitric Oxide Synthase: a Paradigm for Pterin Function Involving a Novel Metal Center

Raman, C.S.,Li, H.,Martasek, P.  et al.
(1998)  Cell(Cambridge,Mass.)  95 : 939 - 950

DOI: 10.1016/S0092-8674(00)81718-3

Structure of Nitric Oxide Synthase Oxygenase Dimer with Pterin and Substrate

Crane, B.R.,Arvai, A.S.,Ghosh, D.K.  et al.
(1998)  Science  279 : 2121 - 2126

DOI: 10.1126/science.279.5359.2121

Spontaneous Rearrangement of Aminoalkylisothioureas into Mercaptoalkylguanidines, a Novel Class of Nitric Oxide Synthase Inhibitors with Selectivity Towards the Inducible Isoform

Southan, G.J.,Zingarelli, B.,O'Connor, M.  et al.
(1996)  Br.J.Pharmacol.  117 : 619 - 632

Chain : A, B
UniProt : P29473 (NOS3_BOVIN)
Reaction: EC: Evidence:
Physiological Direction:
H(+) + 2 L-arginine + 3 NADPH + 4 O2 = 4 H2O + 2 L-citrulline + 3 NADP(+) + 2 nitric oxide 1.14.13.39 UniProtKB:P29474
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