Brand  (β version)

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Ligands
Code Name Link
ACT Acetate ion
CAC Cacodylate ion
NAD Nicotinamide-adenine-dinucleotide
ZN Zinc ion
Code : 1D1S
Header : OXIDOREDUCTASE
Title : WILD-TYPE HUMAN SIGMA (CLASS IV) ALCOHOL DEHYDROGENASE
Release Data : 1999-09-29
Compound :
mol_id molecule chains synonym
1 ALCOHOL DEHYDROGENASE CLASS IV SIGMA CHAIN A,B,C,D RETINOL DEHYDROGENASE, GASTRIC ALCOHOL DEHYDROGENASE
ec: 1.1.1.1
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
expression_system_vector: PKK223-3 AMPICILLIN SELECTABLE VECTOR FROM PHARMACIA
Authors : Xie, P.T., Hurley, T.D.
Keywords : ROSSMAN OR DINUCLEOTIDE FOLD, OXIDOREDUCTASE
Exp. method : X-RAY DIFFRACTION ( 2.5 Å )
Citation :

Methionine-141 directly influences the binding of 4-methylpyrazole in human sigma sigma alcohol dehydrogenase.

Xie, P.T.,Hurley, T.D.
(1999)  Protein Sci.  8 : 2639 - 2644

PubMed: 10631979

X-ray structure of human class IV sigma-sigma alcohol dehydrogenase

Xie, P.T.,Parsons, S.H.,Speckhard, D.C.  et al.
(1997)  J.Biol.Chem.  272 : 18558 - 18563

DOI: 10.1074/jbc.272.30.18558

Chain : A, B, C, D
UniProt : P40394 (ADH7_HUMAN)
Reaction : An alcohol + NAD(+) = an aldehyde or ketone + NADH.