Brand  (β version)

PDB ID: 1D1G

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Ligands
Code Name Style Show Link
MTX Methotrexate PoSSuM
NDP Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate PoSSuM
Non-standard Residues
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Structure summary

Code : 1D1G   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : DIHYDROFOLATE REDUCTASE FROM THERMOTOGA MARITIMA
Release Data : 2000-03-31
Compound :
mol_id molecule chains
1 DIHYDROFOLATE REDUCTASE A,B
ec: 1.5.1.3
Source :
mol_id organism_scientific expression_system
1 Thermotoga maritima  (taxid:2336) Escherichia coli  (taxid:562)
expression_system_plasmid: PTD(TRC)
other_details: GENOMIC LIBRARY
Authors : Dams, T., Auerbach, G., Bader, G., Ploom, T., Huber, R., Jaenicke, R.
Keywords : DIMER, HYPERTHERMOPHILE, OXIDOREDUCTASE
Exp. method : X-RAY DIFFRACTION ( 2.10 Å )
Citation :

The crystal structure of dihydrofolate reductase from Thermotoga maritima: molecular features of thermostability.

Dams, T.,Auerbach, G.,Bader, G.  et al.
(2000)  J.Mol.Biol.  297 : 659 - 672

PubMed: 10731419
DOI: 10.1006/jmbi.2000.3570

Reaction

Chain : A, B
UniProt : Q60034 (DYR_THEMA)
Reaction: EC: Evidence:
Physiological Direction:
(6S)-5,6,7,8-tetrahydrofolate + NADP(+) = 7,8-dihydrofolate + H(+) + NADPH 1.5.1.3 PROSITE- ProRule:PRU00660
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