Brand  (β version)

PDB ID: 1D0C

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Ligands
Code Name Style Show Link
ACT Acetate ion PoSSuM
CAD Cacodylic acid PoSSuM
GOL Glycerol PoSSuM
HEM Protoporphyrin ix containing Fe PoSSuM
INE 3-bromo-7-nitroindazole PoSSuM
ZN Zinc ion PoSSuM
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Structure summary

Code : 1D0C   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : BOVINE ENDOTHELIAL NITRIC OXIDE SYNTHASE HEME DOMAIN COMPLEXED WITH 3-BROMO-7-NITROINDAZOLE (H4B FREE)
Release Data : 2001-11-21
Compound :
mol_id molecule chains
1 BOVINE ENDOTHELIAL NITRIC OXIDE SYNTHASE HEME DOMAIN A,B
ec: 1.14.13.39
Source :
mol_id organism_scientific organism_common expression_system
1 Bos taurus  (taxid:9913) Cattle Escherichia coli  (taxid:562)
cell: ENDOTHELIAL CELLS
Authors : Raman, C.S., Li, H., Martasek, P., Southan, G.J., Masters, B.S.S., Poulos, T.L.
Keywords : ALPHA-BETA FOLD, OXIDOREDUCTASE
Exp. method : X-RAY DIFFRACTION ( 1.65 Å )
Citation :

Crystal structure of nitric oxide synthase bound to nitro indazole reveals a novel inactivation mechanism.

Raman, C.S.,Li, H.,Martasek, P.  et al.
(2001)  Biochemistry  40 : 13448 - 13455

PubMed: 11695891
DOI: 10.1021/bi010957u

Crystal Structure of Constitutive Endothelial Nitric Oxide Synthase: a Paradigm for Pterin Function Involving a Novel Metal Center

Raman, C.S.,Li, H.,Martasek, P.  et al.
(1998)  Cell(Cambridge,Mass.)  95 : 939 - 950

DOI: 10.1016/S0092-8674(00)81718-3

Structure of Nitric Oxide Synthase Oxygenase Dimer with Pterin and Substrate

Crane, B.R.,Arvai, A.S.,Ghosh, D.K.  et al.
(1998)  Science  279 : 2121 - 2126

DOI: 10.1126/science.279.5359.2121

The Structure of Nitric Oxide Synthase Oxygenase Domain and Inhibitor Complexes

Crane, B.R.,Arvai, A.S.,Gachhui, R.  et al.
(1997)  Science  278 : 425 - 431

DOI: 10.1126/science.278.5337.425

Reaction

Chain : A, B
UniProt : P29473 (NOS3_BOVIN)
Reaction: EC: Evidence:
Physiological Direction:
H(+) + 2 L-arginine + 3 NADPH + 4 O2 = 4 H2O + 2 L-citrulline + 3 NADP(+) + 2 nitric oxide 1.14.13.39 UniProtKB:P29474
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