Het-PDB Navi2 (PDB: 1CZQ)

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Ligands
Code	Name		Style	Show	Link
CL	Chloride ion				PoSSuM

Glycosylation
Code	Name	Emphasize

Modification
Code	Name	Show
ACE	Acetyl group

Download interaction data: 1CZQ

Code :

1CZQ PDBj RCSB PDB PDBe

Header :

Viral protein/inhibitor

Title :

CRYSTAL STRUCTURE OF THE D10-P1/IQN17 COMPLEX: A D-PEPTIDE INHIBITOR OF HIV-1 ENTRY BOUND TO THE GP41 COILED-COIL POCKET.

Release Data :

1999-10-13

Compound :

mol_id	molecule	chains	synonym
1	FUSION PROTEIN BETWEEN THE HYDROPHOBIC POCKET OF HIV GP41 AND GCN4-PIQI	A	IQN17
	fragment: HYDROPHOBIC POCKET

mol_id	molecule	chains	synonym
2	D-PEPTIDE INHIBITOR	D	D10-P1

Source :

mol_id	organism_scientific	organism_common
1	Saccharomyces cerevisiae, Human immunodeficiency virus (taxid:4932,12721)	Baker's yeast,
	strain: ,

mol_id	organism_scientific
2
	synthetic: yes other_details: THIS PEPTIDE WAS CHEMICALLY SYNTHESIZED

Authors :

Eckert, D.M., Malashkevich, V.N., Hong, L.H., Carr, P.A., Kim, P.S.

Keywords :

ENVELOPE GLYCOPROTEIN, Viral protein-inhibitor COMPLEX

Exp. method :

X-RAY DIFFRACTION ( 1.50 Å )

Citation :

Inhibiting HIV-1 entry: discovery of D-peptide inhibitors that target the gp41 coiled-coil pocket.

Eckert, D.M.,Malashkevich, V.N.,Hong, L.H. et al.
(1999) Cell(Cambridge,Mass.) 99 : 103 - 115

Crystal structure of GCN4-pIQI, a trimeric coiled-coil with buried polar residues.

(1998) J.Mol.Biol. 284 : 859 - 865

Core structure of gp41 from the HIV envelope glycoprotein

(1997) Cell(Cambridge,Mass.) 89 : 15613 - 15617

PDB ID: 1CZQ