Brand  (β version)

color scheme of protein:

hetatm:

x
information
centroid:
interaction residue:

chain:

Ligands
Code Name Link
EPE 4-(2-hydroxyethyl)-1-piperazine ethanesulfonic acid
Code : 1CZB
Header : TRANSFERASE
Title : ATOMIC RESOLUTION ASV INTEGRASE CORE DOMAIN FROM HEPES
Release Data : 1999-09-08
Compound :
mol_id molecule chains
1 AVIAN SARCOMA VIRUS INTEGRASE A
fragment: CATALYTIC CORE DOMAIN
mutation: INS(P48, L49, R50, E51, N208, L209)
Source :
mol_id organism_scientific expression_system
1 Avian sarcoma virus  (taxid:11876) Escherichia coli  (taxid:562)
expression_system_plasmid: PRC23IN(52-207)
Authors : Lubkowski, J., Dauter, Z., Yang, F., Alexandratos, J., Merkel, G., Skalka, A.M., Wlodawer, A.
Keywords : MIXED BETA-SHEET SURROUNDED BY ALPHA-HELICES, TRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 1.06 Å )
Citation :

Atomic resolution structures of the core domain of avian sarcoma virus integrase and its D64N mutant.

Lubkowski, J.,Dauter, Z.,Yang, F.  et al.
(1999)  Biochemistry  38 : 13512 - 13522

PubMed: 10521258
DOI: 10.1021/bi991362q

Chain : A
UniProt : P03354 (POL_RSVP)
Reaction : Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
Endonucleolytic cleavage to 5'- phosphomonoester.