Brand  (β version)

PDB ID: 1CXV

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Ligands
Code Name Style Show Link
ZN Zinc ion PoSSuM
CA Calcium ion PoSSuM
CBP 2-{4-[4-(4-chloro-phenoxy)-benzenesulfonyl]-tetrahydro-pyran-4-yl}-N-hydroxy-acetamide PoSSuM
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Structure summary

Code : 1CXV   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : STRUCTURE OF RECOMBINANT MOUSE COLLAGENASE-3 (MMP-13)
Release Data : 2000-08-30
Compound :
mol_id molecule chains synonym
1 PROTEIN (COLLAGENASE-3) A,B MATRIX METALLOPROTEINASE, MMP-13
ec: 3.4.24.-
fragment: CATALYTIC DOMAIN
Source :
mol_id organism_scientific organism_common
1 Mus musculus  (taxid:10090) House mouse
Authors : Botos, I., Meyer, E., Swanson, S.M., Lemaitre, V., Eeckhout, Y., Meyer, E.F.
Keywords : METALLOPROTEASE, GLYCOPROTEIN, COLLAGEN DEGRADATION, HYDROLASE
Exp. method : X-RAY DIFFRACTION ( 2.00 Å )
Citation :

Structure of recombinant mouse collagenase-3 (MMP-13).

Botos, I.,Meyer, E.,Swanson, S.M.  et al.
(1999)  J.Mol.Biol.  292 : 837 - 844

PubMed: 10525409
DOI: 10.1006/jmbi.1999.3068

Crystal Structures of Mmp-1 and-13 Reveal the Structural Basis for Selectivity of Collagenase Inhibitors

Lovejoy, B.,Welch, A.R.,Carr, S.  et al.
(1999)  Nat.Struct.Biol.  6 : 217

DOI: 10.1038/6657

The Recombinant Catalytic Domain of Mouse Collagenase-3 Depolymerizes Type I Collagen by Cleaving its Aminotelopeptides

Lemaitre, V.,Jungbluth, A.,Eeckhout, Y.
(1997)  Biochem.Biophys.Res.Commun.  230 : 202

DOI: 10.1006/bbrc.1996.5924

Reaction

Chain : A, B
UniProt : P33435 (MMP13_MOUSE)
Reaction : -
Cofactor: Evidence: Note:
Ca(2+) ECO:0000269 | PubMed:10525409
Can bind about 5 Ca(2+) ions per subunit.
Zn(2+) ECO:0000269 | PubMed:10525409
Binds 2 Zn(2+) ions per subunit.