Brand  (β version)

color scheme of protein:

hetatm:

x
information
centroid:
interaction residue:

chain: Hide other chain(s)

Ligands
Code Name Link
ACT Acetate ion
BMA Beta-D-mannose
CA Calcium ion
CL Chloride ion
FUC Alpha-L-fucose
HEM Protoporphyrin ix containing Fe
MAN Alpha-D-mannose
NAG N-acetyl-D-glucosamine
SO4 Sulfate ion
Modified Residues
Code Name Link
CSO S-hydroxycysteine
Code : 1CXP
Header : OXIDOREDUCTASE
Title : CRYOGENIC CRYSTAL STRUCTURE OF HUMAN MYELOPEROXIDASE ISOFORM C
Release Data : 2000-04-24
Compound :
mol_id molecule chains
1 MYELOPEROXIDASE A,B
ec: 1.11.1.7
fragment: LIGHT CHAIN
mol_id molecule chains
2 MYELOPEROXIDASE C,D
ec: 1.11.1.7
fragment: HEAVY CHAIN
Source :
mol_id organism_scientific organism_common
1 Homo sapiens  (taxid:9606) Human
tissue: BLOOD
cell: NEUTROPHIL
mol_id organism_scientific organism_common
2 Homo sapiens  (taxid:9606) Human
tissue: BLOOD
cell: NEUTROPHIL
Authors : Fiedler, T.J., Fenna, R.E.
Keywords : HEME-PROTEIN, PEROXIDASE, OXIDOREDUCTASE
Exp. method : X-RAY DIFFRACTION ( 1.80 Å )
Citation :

X-ray crystal structure and characterization of halide-binding sites of human myeloperoxidase at 1.8 A resolution.

Fiedler, T.J.,Davey, C.A.,Fenna, R.E.
(2000)  J.Biol.Chem.  275 : 11964 - 11971

PubMed: 10766826
DOI: 10.1074/jbc.275.16.11964

Structure of the Green Heme in Myeloperoxidase

Fenna, R.,Zeng, J.,Davey, C.
(1995)  Arch.Biochem.Biophys.  316 : 653

DOI: 10.1006/abbi.1995.1086

2.3 Angstrom Resolution X-Ray Crystal Structure of the Bisubstrate Analogue Inhibitor Salicylhydroxamic Acid Bound to Human Myeloperoxidase: A Model for a Prereaction Complex with Hydrogen Peroxide

Davey, C.A.,Fenna, R.E.
(1996)  Biochemistry  35 : 10967

DOI: 10.1021/bi960577m

X-Ray Crystal Structure of Canine Myeloperoxidase at 3 Angstrom Resolution

Zeng, J.,Fenna, R.E.
(1992)  J.Mol.Biol.  226 : 185

Site-Directed Mutagenesis of Human Myeloperoxidase: Further Identification of Residues Involved in Catalytic Activity and Heme Interaction

Jacquet, A.,Garcia-Quintana, L.,Deleersnyder, V.  et al.
(1994)  Biochem.Biophys.Res.Commun.  202 : 73

DOI: 10.1006/bbrc.1994.1895

Chain : C, D
UniProt : P05164 (PERM_HUMAN)
Reaction : Cl(-) + H(2)O(2) + H(+) = HClO + H(2)O.