Brand  (β version)

PDB ID: 1CWZ

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Ligands
Code Name Style Show Link
DXX Methylmalonic acid PoSSuM
Non-standard Residues
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DAR D-arginine
DGL D-glutamic acid
DIL D-isoleucine
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NH2 Amino group

Structure summary

Code : 1CWZ   PDBj   RCSB PDB   PDBe
Header : DNA BINDING PROTEIN
Title : Solution structure of the analogue retro-inverso (MA-S)REGRIGGC in contact with the monoclonal antibody MAB 4X11, NMR, 7 structures
Release Data : 1999-09-03
Compound :
mol_id molecule chains
1 HISTONE H3 A
fragment: C-TERMINAL DOMAIN: Residues 130-135
Source :
mol_id organism_scientific
1
synthetic: yes
other_details: THE PEPTIDE WAS CHEMICALLY SYNTHESIZED. THE SEQUENCE CGG WAS ADDED AS A LINKER TO THE DEXTRAN MATRIX IN BIACORE EXPERIMENTS VIA THE CYS THIOL GROUP. NH2-CO WAS ADDED AT THE C-TERMINAL EXTREMITY OF THE RETRO-INVERSO PEPTIDE IN ORDER TO MIMIC THE N-TERMINAL OF THE PARENT PEPTIDE. ALL NON GLYCINE RESIDUE PRESENT A D-CONFIGURATION EXCEPT CYS. TWO RI(MA) DIASTEREISOMERS WERE OBTAINED AND COULDN'T BE SEPARATED.
Authors : Phan Chan Du, A., Petit, M.C., Guichard, G., Briand, J.P., Muller, S., Cung, M.T.
Keywords : PSEUDOMIMETIC, SYNTHETIC PEPTIDE, RETRO-INVERSO ANALOGUE, TR-NOE, ANTIGEN- ANTIBODY COMPLEX, DNA BINDING PROTEIN
Exp. method : SOLUTION NMR
Citation :

Structure of antibody-bound peptides and retro-inverso analogues. A transferred nuclear Overhauser effect spectroscopy and molecular dynamics approach.

Phan-Chan-Du, A.,Petit, M.C.,Guichard, G.  et al.
(2001)  Biochemistry  40 : 5720 - 5727

PubMed: 11341837
DOI: 10.1021/bi001151h