Brand  (β version)

PDB ID: 1CWA

Hetero Atom Contents

  The number of atoms exceeds 100,000.
  So, it can not be displayed here.

Select unit:

Select chain:   Sequence  

Data format:   

Color scheme of protein:

Ligands
Code Name Style Show Link
Non-standard Residues
Code Name Show
ABA Alpha-aminobutyric acid
BMT 4-methyl-4-[(E)-2-butenyl]-4,N-methyl-threonine
DAL D-alanine
MLE N-methylleucine
MVA N-methylvaline
SAR Sarcosine
Glycosylation
Code Name Emphasize
Modification
Code Name Show

Structure summary

Code : 1CWA   PDBj   RCSB PDB   PDBe
Header : ISOMERASE/IMMUNOSUPPRESSANT
Title : X-RAY STRUCTURE OF A MONOMERIC CYCLOPHILIN A-CYCLOSPORIN A CRYSTAL COMPLEX AT 2.1 ANGSTROMS RESOLUTION
Release Data : 1996-01-29
Compound :
mol_id molecule chains synonym
1 PEPTIDYL-PROLYL CIS-TRANS ISOMERASE A A PPIASE, ROTAMASE, CYCLOPHILIN A
ec: 5.2.1.8
mol_id molecule chains synonym
2 CYCLOSPORIN A C CYCLOSPORINE, CICLOSPORIN, CICLOSPORINE
Source :
mol_id organism_scientific organism_common expression_system
1 HOMO SAPIENS  (taxid:9606) HUMAN ESCHERICHIA COLI  (taxid:562)
gene: CYCLOPHILIN
expression_system_gene: CYCLOPHILIN
mol_id organism_scientific
2 TOLYPOCLADIUM INFLATUM  (taxid:29910)
synthetic: yes
Authors : Mikol, V., Kallen, J., Walkinshaw, M.D.
Keywords : ISOMERASE-IMMUNOSUPPRESSANT COMPLEX, CYCLOPHILIN-CYCLOSPORIN COMPLEX, CYCLOSPORIN A, IMMUNOSUPPRESSANT, CYCLOPHILIN
Exp. method : X-RAY DIFFRACTION ( 2.10 Å )
Citation :

X-Ray Structure of a Monomeric Cyclophilin A-Cyclosporin a Crystal Complex at 2.1 A Resolution.

Mikol, V.,Kallen, J.,Pflugl, G.  et al.
(1993)  J.Mol.Biol.  234 : 1119

PubMed: 8263916
DOI: 10.1006/JMBI.1993.1664

Crystallization of the Complex between Cyclophilin a and Cyclosporin Derivatives: The Use of Cross- Seeding.

Mikol, V.,Duc, D.
(1994)  Acta Crystallogr.,Sect.D  50 : 543

PubMed: 15299416
DOI: 10.1107/S0907444994001800

The X-Ray Structure of (Mebm2T)1-Cyclosporin Complexed with Cyclophilin a Provides an Explanation for its Anomalously High Immunosuppressive Activity.

Mikol, V.,Kallen, J.,Walkinshaw, M.D.
(1994)  Protein Eng.  7 : 597

PubMed: 8073029

Improved Binding Affinity for Cyclophilin a by a Cyclosporin Derivative Singly Modified at its Effector Domain.

Papageorgiou, C.,Florineth, A.,Mikol, V.
(1994)  J.Med.Chem.  37 : 3674

PubMed: 7966126

X-Ray Structure of a Decameric Cyclophilin- Cyclosporin Crystal Complex.

Pflugl, G.,Kallen, J.,Schirmer, T.  et al.
(1993)  Nature  361 : 91

PubMed: 8421501
DOI: 10.1038/361091A0

Reaction

Chain : A
UniProt : P05092 (multiple entry names are found)
Reaction : -