Het-PDB Navi2 (PDB: 1CW4)

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Ligands
Code	Name	Link
AKG	2-oxoglutaric acid	PoSSuM
MN	Manganese (II) ion	PoSSuM
SO4	Sulfate ion	PoSSuM

Non-standard Residues
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Glycosylation
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Download interaction data: 1CW4

Code :

1CW4 PDBj RCSB PDB PDBe

Header :

OXIDOREDUCTASE

Title :

CRYSTAL STRUCTURE OF K230M ISOCITRATE DEHYDROGENASE IN COMPLEX WITH ALPHA-KETOGLUTARATE

Release Data :

1999-09-01

Compound :

mol_id	molecule	chains
1	ISOCITRATE DEHYDROGENASE	A
	ec: 1.1.1.42 mutation: K230M

Source :

mol_id	organism_scientific	expression_system
1	Escherichia coli (taxid:562)	Escherichia coli (taxid:562)
	expression_system_plasmid: PTK513 other_details: VARIANT OF E. COLI STRAIN JLK1 WITH NO WILD- TYPE ISOCITRATE DEHYDROGENASE GENE

Authors :

Stroud, M.R., Finer-Moore, J.

Keywords :

OXIDOREDUCTASE, Isocitrate Dehydrogenase, mutant

Exp. method :

X-RAY DIFFRACTION ( 2.10 Å )

Citation :

Active site water molecules revealed in the 2.1 A resolution structure of a site-directed mutant of isocitrate dehydrogenase.

Cherbavaz, D.B.,Lee, M.E.,Stroud, R.M. et al.
(2000) J.Mol.Biol. 295 : 377 - 385

Mutational Analysis of the Catalytic Residues Lysine 230 and Tyrosine 160 in the NADP+ Dependent Isocitrate dehydrogenase from Escherichia coli

Lee, M.E.,Dyer, D.H.,Klein, O.D. et al.
(1995) Biochemistry 34 : 378 - 384

Catalytic Mechanism of NADP+-dependent Isocitrate Dehydrogenase: Implications from the Structures of Magnesium-isocitrate and NADP+ complexes

Hurley, J.H.,Dean, A.M.,Koshland Jr., D.E. et al.
(1991) Biochemistry 30 : 8671 - 8678

Chain :

UniProt :

P08200 (IDH_ECOLI)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
D-threo-isocitrate + NADP(+) = 2-oxoglutarate + CO2 + NADPH	1.1.1.42	PubMed:21151122, PubMed:3112144, PubMed:7761851, PubMed:7819221
D-threo-isocitrate + NADP(+) = 2-oxoglutarate + CO2 + NADPH	-

PDB ID: 1CW4