Het-PDB Navi2 (PDB: 1CVZ)

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Ligands
Code	Name		Style	Show	Link
C48	N1-(1-dimethylcarbamoyl-2-phenyl-ethyl)-2-oxo-n4-(2-pyridin-2-yl-ethyl)-succinamide				PoSSuM

Non-standard Residues
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Glycosylation
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Download interaction data: 1CVZ

Code :

1CVZ PDBj RCSB PDB PDBe

Header :

HYDROLASE

Title :

CRYSTAL STRUCTURE ANALYSIS OF PAPAIN WITH CLIK148(CATHEPSIN L SPECIFIC INHIBITOR)

Release Data :

2000-08-30

Compound :

mol_id	molecule	chains
1	PAPAIN	A
	ec: 3.4.22.2 fragment: RESIDUES 134-345

Source :

mol_id	organism_scientific	organism_common
1	Carica papaya (taxid:3649)	Papaya

Authors :

Tsuge, H.

Keywords :

PAPAIN, CLIK148, CATHEPSIN L INHIBITOR, SULFHYDRYL PROTEINASE, HYDROLASE

Exp. method :

X-RAY DIFFRACTION ( 1.70 Å )

Citation :

Inhibition mechanism of cathepsin L-specific inhibitors based on the crystal structure of papain-CLIK148 complex.

Tsuge, H.,Nishimura, T.,Tada, Y. et al.
(1999) Biochem.Biophys.Res.Commun. 266 : 411 - 416

Chain :

UniProt :

P00784 (PAPA1_CARPA)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
Hydrolysis of proteins with broad specificity for peptide bonds, but preference for an amino acid bearing a large hydrophobic side chain at the P2 position. Does not accept Val in P1'.	3.4.22.2	PubMed:21416241, PubMed:23151624, PubMed:2404797
	-	PubMed:21416241, PubMed:23151624, PubMed:2404797

PDB ID: 1CVZ