Brand  (β version)

PDB ID: 1CVW

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Ligands
Code Name Style Show Link
0GE N-{[5-(dimethylamino)naphthalen-1-yl]sulfonyl}-L-alpha-glutamyl-N-[(2s,3s)-6-carbamimidamido-1-chloro-2-hydroxyhexan-3-yl]glycinamide PoSSuM
CA Calcium ion PoSSuM
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Structure summary

Code : 1CVW   PDBj   RCSB PDB   PDBe
Header : HYDROLASE/HYDROLASE INHIBITOR
Title : Crystal structure of active site-inhibited human coagulation factor VIIA (DES-GLA)
Release Data : 1999-08-31
Compound :
mol_id molecule chains
1 COAGULATION FACTOR VIIA (LIGHT CHAIN) (DES-GLA) L
ec: 3.4.21.21
mol_id molecule chains
2 COAGULATION FACTOR VIIA (HEAVY CHAIN) (DES-GLA) H
ec: 3.4.21.21
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Cricetulus griseus  (taxid:10029)
expression_system_common: Chinese hamster
expression_system_organ: OVARY
mol_id organism_scientific organism_common expression_system
2 Homo sapiens  (taxid:9606) Human Cricetulus griseus  (taxid:10029)
expression_system_common: Chinese hamster
expression_system_organ: OVARY
Authors : Kemball-Cook, G., Johnson, D.J.D., Tuddenham, E.G.D., Harlos, K.
Keywords : BLOOD COAGULATION, FACTOR VIIA, SERINE PROTEASE, EGF, HYDROLASE-HYDROLASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 2.28 Å )
Citation :

Crystal structure of active site-inhibited human coagulation factor VIIa (des-Gla).

Kemball-Cook, G.,Johnson, D.J.,Tuddenham, E.G.  et al.
(1999)  J.Struct.Biol.  127 : 213 - 223

PubMed: 10544046
DOI: 10.1006/jsbi.1999.4158

Crystallization and Preliminary X-ray Analysis of Active Site-Inhibited Human Coagulation Factor VIIa (des-Gla)

Johnson, D.J.,Nugent, P.G.,Tuddenham, E.G.  et al.
(1999)  J.Struct.Biol.  125 : 90 - 93

DOI: 10.1006/jsbi.1998.4078

Reaction

Chain : H
UniProt : P08709 (FA7_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
Selective cleavage of Arg-|-Ile bond in factor X to form factor Xa. 3.4.21.21 -
-