Brand  (β version)

  The number of atoms exceeds 100,000.
  So, it can not be displayed here.

Select unit:

Select hetatm:   

close
information
centroid:
interaction residue:

Select chain:   Sequence  

Data format:   

Color scheme of protein:

Ligands
Code Name Style Show Link
MG Magnesium ion
FOK Forskolin
3PO Triphosphate
MES 2-(N-morpholino)-ethanesulfonic acid
103 2',5'-dideoxy-adenosine 3'-monophosphate
CL Chloride ion
GSP 5'-guanosine-diphosphate-monothiophosphate
Non-standard Residues
Code Name Show
Glycosylation
Code Name Emphasize
Modification
Code Name Show
Code : 1CUL   PDBj   RCSB PDB   PDBe
Header : Lyase/Lyase/Signaling protein
Title : COMPLEX OF GS-ALPHA WITH THE CATALYTIC DOMAINS OF MAMMALIAN ADENYLYL CYCLASE: COMPLEX WITH 2',5'-DIDEOXY-ADENOSINE 3'-TRIPHOSPHATE AND MG
Release Data : 2001-01-10
Compound :
mol_id molecule chains synonym
1 TYPE V ADENYLYL CYCLASE A ATP PYROPHOSPHATE-LYASE
ec: 4.6.1.1
fragment: C1A DOMAIN
mutation: V476M
mol_id molecule chains synonym
2 TYPE II ADENYLYL CYCLASE B ATP PYROPHOSPHATE-LYASE, ADENYLYL CYCLASE
ec: 4.6.1.1
fragment: C2A DOMAIN
mol_id molecule chains synonym
3 GUANINE NUCLEOTIDE-BINDING PROTEIN G(S) C ADENYLATE CYCLASE-STIMULATING G ALPHA PROTEIN
fragment: GS(ALPHA)
mutation: TRYPSINIZED, SHORT FORM
Source :
mol_id organism_scientific organism_common expression_system
1 Canis lupus familiaris  (taxid:9615) Dog Escherichia coli  (taxid:562)
strain: familiaris
organ: HEART
expression_system_vector_type: PLASMID
expression_system_plasmid: PQE60-H6-VC1(580)
mol_id organism_scientific organism_common expression_system
2 Rattus norvegicus  (taxid:10116) Norway rat Escherichia coli  (taxid:562)
organ: BRAIN
expression_system_vector_type: PLASMID
expression_system_plasmid: PQE60-ARGC-IIC2
mol_id organism_scientific organism_common expression_system
3 Bos taurus  (taxid:9913) Cattle Escherichia coli  (taxid:562)
organ: UDDER
expression_system_vector_type: PLASMID
expression_system_plasmid: PQE60-GSALPHA-H
Authors : Tesmer, J.J.G., Dessauer, C.A., Sunahara, R.K., Johnson, R.A., Gilman, A.G., Sprang, S.R.
Keywords : COMPLEX (LYASE-HYDROLASE), HYDROLASE, SIGNAL TRANSDUCING PROTEIN, CYCLASE, EFFECTOR ENZYME, LYASE-HYDROLASE COMPLEX, LYASE/LYASE/SIGNALING PROTEIN, Lyase-Lyase-Signaling protein complex
Exp. method : X-RAY DIFFRACTION ( 2.4 Å )
Citation :

Molecular basis for P-site inhibition of adenylyl cyclase.

Tesmer, J.J.,Dessauer, C.W.,Sunahara, R.K.  et al.
(2000)  Biochemistry  39 : 14464 - 14471

PubMed: 11087399
DOI: 10.1021/bi0015562

Chain : A
UniProt : P30803 (ADCY5_CANLF)
Reaction: EC: Evidence:
Physiological Direction:
ATP = 3',5'-cyclic AMP + diphosphate 4.6.1.1 PubMed:10427002, PubMed:11087399, PubMed:15591060, PubMed:1618857, PubMed:16766715, PubMed:19243146, PubMed:8428899
-
Chain : B
UniProt : P26769 (ADCY2_RAT)
Reaction: EC: Evidence:
Physiological Direction:
ATP = 3',5'-cyclic AMP + diphosphate 4.6.1.1 PubMed:10427002, PubMed:11087399, PubMed:15591060, PubMed:16766715, PubMed:1719547, PubMed:19243146, PubMed:21596131, PubMed:22906005, PubMed:24363043, PubMed:7761832
-
Chain : C
UniProt : P04896 (GNAS2_BOVIN)
Reaction : -