Brand  (β version)

  The number of atoms exceeds 100,000.
  So, it can not be displayed here.

Select unit:

Select hetatm:   

close
information
centroid:
interaction residue:

Select chain:   Sequence  

Data format:   

Color scheme of protein:

Ligands
Code Name Style Show Link
MYR Myristic acid
Non-standard Residues
Code Name Show
TPO Phosphothreonine
TYI 3,5-diiodotyrosine
Glycosylation
Code Name Emphasize
Modification
Code Name Show
Code : 1CTP   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE/TRANSFERASE INHIBITOR
Title : STRUCTURE OF THE MAMMALIAN CATALYTIC SUBUNIT OF CAMP-DEPENDENT PROTEIN KINASE AND AN INHIBITOR PEPTIDE DISPLAYS AN OPEN CONFORMATION
Release Data : 1994-01-31
Compound :
mol_id molecule chains
1 cAMP-DEPENDENT PROTEIN KINASE E
ec: 2.7.1.37
mol_id molecule chains
2 cAMP-dependent protein kinase inhibitor, alpha form I
Source :
mol_id organism_scientific organism_common
1 Sus scrofa  (taxid:9823) Pig
mol_id organism_scientific organism_common
2 Homo sapiens  (taxid:9606) Human
synthetic: yes
Authors : Karlsson, R., Zheng, J., Xuong, N.H., Taylor, S.S., Sowadski, J.M.
Keywords : TRANSFERASE(PHOSPHOTRANSFERASE), TRANSFERASE-TRANSFERASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 2.9 Å )
Citation :

Structure of the mammalian catalytic subunit of cAMP-dependent protein kinase and an inhibitor peptide displays an open conformation.

Karlsson, R.,Zheng, J.,Xuong, N.  et al.
(1993)  Acta Crystallogr.,Sect.D  49 : 381 - 388

PubMed: 15299513
DOI: 10.1107/S0907444993002306

Crystal-Structure of the Catalytic Subunit of Camp-Dependent Protein-Kinase Complexed with a Mgatp and Peptide Inhibitor

Zheng, J.,Knighton, D.R.,Xuong, N.-H.  et al.
(1993)  Biochemistry  32 : 2154

2.0 Angstroms Refined Crystal Structure of the Catalytic Subunit of Camp-Dependent Protein Kinase Complexed with a Peptide Inhibitor and Detergent

Knighton, D.R.,Bell, S.M.,Zheng, J.  et al.
(1993)  Acta Crystallogr.,Sect.D  49 : 357

2.2 Angstroms Refined Crystal-Structure of the Catalytic Subunit of Camp-Dependent Protein-Kinase Complexed with Mnatp and a Peptide Inhibitor

Zheng, J.H.,Trafny, E.A.,Knighton, D.R.  et al.
(1993)  Acta Crystallogr.,Sect.D  49 : 362

Crystal Structure of the Catalytic Subunit of Cyclic Adenosine Monophosphate-Dependent Protein Kinase

Knighton, D.R.,Zheng, J.,Eyck, L.F.T.  et al.
(1991)  Science  253 : 407

Structure of a Peptide Inhibitor Bound to the Catalytic Subunit of Cyclic Adenosine Monophosphate-Dependent Protein Kinase

Knighton, D.R.,Zheng, J.,Eyck, L.F.T.  et al.
(1991)  Science  253 : 414

Expression of the Catalytic Subunit of Camp-Dependent Protein Kinase in Escherichia Coli

Slice, L.W.,Taylor, S.S.
(1989)  J.Biol.Chem.  264 : 20940

Chain : E
UniProt : P36887 (KAPCA_PIG)
Reaction: EC: Evidence:
Physiological Direction:
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein] 2.7.11.11 -
-
ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein] 2.7.11.11 -
-
Chain : I
UniProt : P61925 (IPKA_HUMAN)
Reaction : -