Brand  (β version)

PDB ID: 1CS0

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Ligands
Code Name Style Show Link
MN Manganese (II) ion PoSSuM
K Potassium ion PoSSuM
CL Chloride ion PoSSuM
PO4 Phosphate ion PoSSuM
ADP Adenosine-5'-diphosphate PoSSuM
ORN L-ornithine PoSSuM
NET Tetraethylammonium ion PoSSuM
Non-standard Residues
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CYG 2-amino-4-(amino-3-oxo-propylsulfanylcarbonyl)-butyric acid
Glycosylation
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Structure summary

Code : 1CS0   PDBj   RCSB PDB   PDBe
Header : LIGASE
Title : Crystal structure of carbamoyl phosphate synthetase complexed at CYS269 in the small subunit with the tetrahedral mimic L-glutamate gamma-semialdehyde
Release Data : 1999-12-10
Compound :
mol_id molecule chains
1 CARBAMOYL PHOSPHATE SYNTHETASE: LARGE SUBUNIT A,C,E,G
ec: 6.3.5.5
mol_id molecule chains
2 CARBAMOYL PHOSPHATE SYNTHETASE: SMALL SUBUNIT B,D,F,H
ec: 6.3.5.5
Source :
mol_id organism_scientific expression_system
1 Escherichia coli  (taxid:562) Escherichia coli  (taxid:562)
expression_system_plasmid: PDP412
mol_id organism_scientific expression_system
2 Escherichia coli  (taxid:562) Escherichia coli  (taxid:562)
expression_system_plasmid: PDP412
Authors : Thoden, J.B., Huang, X., Raushel, F.M., Holden, H.M.
Keywords : TETRAHEDRAL ANALOG, AMIDOTRANSFERASE, SUBSTRATE CHANNELING, LIGASE
Exp. method : X-RAY DIFFRACTION ( 2.00 Å )
Citation :

The small subunit of carbamoyl phosphate synthetase: snapshots along the reaction pathway.

Thoden, J.B.,Huang, X.,Raushel, F.M.  et al.
(1999)  Biochemistry  38 : 16158 - 16166

PubMed: 10587438
DOI: 10.1021/bi991741j

Reaction

Chain : A, C, E, G
UniProt : P00968 (CARB_ECOLI)
Reaction: EC: Evidence:
Physiological Direction:
2 ATP + H2O + hydrogencarbonate + L-glutamine = 2 ADP + carbamoyl phosphate + 2 H(+) + L-glutamate + phosphate 6.3.5.5 HAMAP- Rule:MF_01210, PubMed:4944634
-
[Carbamoyl phosphate synthase large chain]
2 ATP + hydrogencarbonate + NH4(+) = 2 ADP + carbamoyl phosphate + 2 H(+) + phosphate 		6.3.4.16 HAMAP- Rule:MF_01210, PubMed:4944634
-
Chain : B, D, F, H
UniProt : P00907 (CARA_ECOLI)
Reaction: EC: Evidence:
Physiological Direction:
2 ATP + H2O + hydrogencarbonate + L-glutamine = 2 ADP + carbamoyl phosphate + 2 H(+) + L-glutamate + phosphate 6.3.5.5 HAMAP- Rule:MF_01209, PubMed:4944634
-
[Carbamoyl phosphate synthase small chain]
H2O + L-glutamine = L-glutamate + NH4(+) 		- HAMAP- Rule:MF_01209, PubMed:4944634
-