Brand  (β version)

PDB ID: 1CR6

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Ligands
Code Name Style Show Link
CPU N-cyclohexyl-N'-(propyl)phenyl urea PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 1CR6   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : CRYSTAL STRUCTURE OF MURINE SOLUBLE EPOXIDE HYDROLASE COMPLEXED WITH CPU INHIBITOR
Release Data : 1999-11-19
Compound :
mol_id molecule chains
1 EPOXIDE HYDROLASE A,B
ec: 3.3.2.3
Source :
mol_id organism_scientific organism_common expression_system
1 Mus musculus  (taxid:10090) House mouse Spodoptera frugiperda  (taxid:7108)
organ: LIVER
expression_system_common: Fall armyworm
expression_system_vector: BACCULOVIRUS
Authors : Argiriadi, M.A., Morisseau, C., Hammock, B.D., Christianson, D.W.
Keywords : HOMODIMER, ALPHA/BETA HYDROLASE FOLD, DISUBSTITUTED UREA INHIBITOR, HYDROLASE
Exp. method : X-RAY DIFFRACTION ( 2.8 Å )
Citation :

Detoxification of environmental mutagens and carcinogens: structure, mechanism, and evolution of liver epoxide hydrolase.

Argiriadi, M.A.,Morisseau, C.,Hammock, B.D.  et al.
(1999)  Proc.Natl.Acad.Sci.USA  96 : 10637 - 10642

PubMed: 10485878
DOI: 10.1073/pnas.96.19.10637

Potent urea and carbamate inhibitors of soluble epoxide hydrolases

Morisseau, C.,Goodrow, M.,Dowdy, D.  et al.
(1999)  Proc.Natl.Acad.Sci.USA  96 : 8849 - 8854

DOI: 10.1073/pnas.96.16.8849

Reaction

Chain : A, B
UniProt : P34914 (HYES_MOUSE)
Reaction: EC: Evidence:
Physiological Direction:
an epoxide + H2O = an ethanediol 3.3.2.10 UniProtKB:P34913
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(9S,10S)-10-hydroxy-9-(phosphooxy)octadecanoate + H2O = (9S,10S)-9,10-dihydroxyoctadecanoate + phosphate 3.1.3.76 UniProtKB:P34913
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8-hydroxy-(11S,12S)-epoxy-(5Z,9E,14Z)-eicosatrienoate + H2O = (8,11R,12S)-trihydroxy-(5Z,9E,14Z)-eicosatrienoate - PubMed:21217101
left-to-right
10-hydroxy-(11S,12S)-epoxy- (5Z,8Z,14Z)-eicosatrienoate + H2O = (10,11S,12R)-trihydroxy-(5Z,8Z,14Z)-eicosatrienoate - PubMed:21217101
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(8S,9R)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H2O = (8S,9S)- dihydroxy-(5Z,11Z,14Z)-eicosatrienoate - PubMed:7840649
left-to-right
(11S,12R)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H2O = (11R,12R)- dihydroxy-(5Z,8Z,14Z)-eicosatrienoate - PubMed:7840649
left-to-right
(11S,12R)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H2O = (11S,12S)- dihydroxy-(5Z,8Z,14Z)-eicosatrienoate - PubMed:7840649
left-to-right
(14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H2O = (14R,15R)- dihydroxy-(5Z,8Z,11Z)-eicosatrienoate - PubMed:7840649
left-to-right
(14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H2O = (14S,15S)- dihydroxy-(5Z,8Z,11Z)-eicosatrienoate - PubMed:7840649
left-to-right
(11R,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H2O = (11S,12S)- dihydroxy-(5Z,8Z,14Z)-eicosatrienoate - PubMed:7840649
left-to-right
(11R,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H2O = (11R,12R)- dihydroxy-(5Z,8Z,14Z)-eicosatrienoate - PubMed:7840649
left-to-right
(8S,9R)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H2O = (8R,9R)- dihydroxy-(5Z,11Z,14Z)-eicosatrienoate - PubMed:7840649
left-to-right
12-phosphooxy-(9Z)-octadecenoate + H2O = 12-hydroxy-(9Z)- octadecenoate + phosphate - UniProtKB:P34913
left-to-right
12-phosphooxy-(9E)-octadecenoate + H2O = 12-hydroxy-(9E)- octadecenoate + phosphate - UniProtKB:P34913
left-to-right
12-(phosphooxy)octadecanoate + H2O = 12-hydroxyoctadecanoate + phosphate - UniProtKB:P34913
left-to-right
8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H2O = 8,9-dihydroxy- (5Z,11Z,14Z)-eicosatrienoate - UniProtKB:P34913
left-to-right
11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H2O = 11,12- dihydroxy-(5Z,8Z,14Z)-eicosatrienoate - UniProtKB:P34913
left-to-right
14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H2O = 14,15- dihydroxy-(5Z,8Z,11Z)-eicosatrienoate - UniProtKB:P34913
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9,10-epoxy-(12Z)-octadecenoate + H2O = 9,10-dihydroxy-(12Z)- octadecenoate - UniProtKB:P34913
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1-tetradecanoyl-sn-glycerol 3-phosphate + H2O = 1- tetradecanoyl-sn-glycerol + phosphate - UniProtKB:P34913
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1-octadecanoyl-sn-glycero-3-phosphate + H2O = 1-octadecanoyl- sn-glycerol + phosphate - UniProtKB:P34913
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1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + H2O = 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + phosphate - UniProtKB:P34913
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1-hexadecanoyl-sn-glycero-3-phosphate + H2O = 1-hexadecanoyl- sn-glycerol + phosphate - UniProtKB:P34913
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1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O = 1-(9Z- octadecenoyl)-sn-glycerol + phosphate - UniProtKB:P34913
left-to-right
(14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H2O = (14R,15R)- dihydroxy-(5Z,8Z,11Z)-eicosatrienoate - PubMed:7840649
left-to-right