Brand  (β version)

PDB ID: 1CQJ

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Ligands
Code Name Style Show Link
COA Coenzyme a PoSSuM
PO4 Phosphate ion PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 1CQJ   PDBj   RCSB PDB   PDBe
Header : LIGASE
Title : CRYSTAL STRUCTURE OF DEPHOSPHORYLATED E. COLI SUCCINYL-COA SYNTHETASE
Release Data : 2000-01-10
Compound :
mol_id molecule chains synonym
1 SUCCINYL-COA SYNTHETASE ALPHA CHAIN A,D SCS-ALPHA
ec: 6.2.1.5
fragment: ALPHA SUBUNIT
mol_id molecule chains synonym
2 SUCCINYL-COA SYNTHETASE BETA CHAIN B,E SCS-BETA
ec: 6.2.1.5
fragment: BETA SUBUNIT
Source :
mol_id organism_scientific expression_system
1 Escherichia coli  (taxid:562) Escherichia coli  (taxid:562)
mol_id organism_scientific expression_system
2 Escherichia coli  (taxid:562) Escherichia coli  (taxid:562)
Authors : Joyce, M.A., Fraser, M.E., James, M.N.G., Bridger, W.A., Wolodko, W.T.
Keywords : ATP-GRASP FOLD, ROSSMANN FOLD, LIGASE
Exp. method : X-RAY DIFFRACTION ( 2.9 Å )
Citation :

ADP-binding site of Escherichia coli succinyl-CoA synthetase revealed by x-ray crystallography.

Joyce, M.A.,Fraser, M.E.,James, M.N.  et al.
(2000)  Biochemistry  39 : 17 - 25

PubMed: 10625475
DOI: 10.1021/bi991696f

A Detailed Structural Description of Escherichia Coli Succinyl-CoA Synthetase

Fraser, M.E.,James, M.N.G.,Bridger, W.A.  et al.
(1999)  J.Mol.Biol.  285 : 1633 - 1653

DOI: 10.1006/jmbi.1998.2324

The crystal structure of succinyl-CoA synthetase from Escherichia coli at 2.5A resolution

Wolodko, W.T.,Fraser, M.E.,James, M.N.G.  et al.
(1994)  J.Biol.Chem.  269 : 10883 - 10890

Crystallization of succinyl-CoA synthetase from Escherichia coli

Wolodko, W.T.,James, M.N.G.,Bridger, W.A.
(1984)  J.Biol.Chem.  259 : 5316 - 5320

Reaction

Chain : A, D
UniProt : P07459 (SUCD_ECOLI)
Reaction: EC: Evidence:
Physiological Direction:
ATP + CoA + succinate = ADP + phosphate + succinyl-CoA 6.2.1.5 HAMAP- Rule:MF_01988, PubMed:10353839
right-to-left HAMAP-Rule:MF_01988, PubMed:10353839
CoA + GTP + succinate = GDP + phosphate + succinyl-CoA - HAMAP-Rule:MF_01988, PubMed:10353839
right-to-left
Chain : B, E
UniProt : P07460 (SUCC_ECOLI)
Reaction: EC: Evidence:
Physiological Direction:
ATP + CoA + succinate = ADP + phosphate + succinyl-CoA 6.2.1.5 HAMAP- Rule:MF_00558, PubMed:10353839, PubMed:7040388
right-to-left HAMAP-Rule:MF_00558, PubMed:10353839
CoA + GTP + succinate = GDP + phosphate + succinyl-CoA - HAMAP-Rule:MF_00558, PubMed:10353839
right-to-left