Brand  (β version)

PDB ID: 1CQE

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Ligands
Code Name Style Show Link
FLP Flurbiprofen PoSSuM
HEM Protoporphyrin ix containing Fe PoSSuM
BOG Octyl beta-D-glucopyranoside PoSSuM
Non-standard Residues
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Glycosylation
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NAG 2-acetamido-2-deoxy-beta-D-glucopyranose
Modification
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Structure summary

Code : 1CQE   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : PROSTAGLANDIN H2 SYNTHASE-1 COMPLEX WITH FLURBIPROFEN
Release Data : 1999-06-30
Compound :
mol_id molecule chains synonym
1 PROTEIN (PROSTAGLANDIN H2 SYNTHASE-1) A,B CYCLOOXYGENASE 1, COX-1, PROSTAGLANDIN-ENDOPEROXIDE SYNTHASE 1
ec: 1.14.99.1
other_details: PROTEIN IS GLYCOSYLATED AT RESIDUES ASN68, ASN144 AND ASN410
Source :
mol_id organism_scientific organism_common
1 Ovis aries  (taxid:9940) Sheep
tissue: SEMINAL VESICLE
Authors : Picot, D., Loll, P.J., Mulichak, A.M., Garavito, R.M.
Keywords : OXIDOREDUCTASE, DIOXYGENASE, PEROXIDASE
Exp. method : X-RAY DIFFRACTION ( 3.1 Å )
Citation :

The X-ray crystal structure of the membrane protein prostaglandin H2 synthase-1.

Picot, D.,Loll, P.J.,Garavito, R.M.
(1994)  Nature  367 : 243 - 249

PubMed: 8121489
DOI: 10.1038/367243a0

Synthesis and Use of Iodinated Nonsteroidal Antiinflammatory Drug Analogs as Crystallographic Probes of the Prostaglandin H2 Synthase Cyclooxygenase Active Site

Loll, P.J.,Picot, D.,Ekabo, O.  et al.
(1996)  Biochemistry  35 : 7330

DOI: 10.1021/bi952776w

The Structural Basis of Aspirin Activity Inferred from the Crystal Structure of Inactivated Prostaglandin H2 Synthase

Loll, P.J.,Picot, D.,Garavito, R.M.
(1995)  Nat.Struct.Biol.  2 : 637

X-Ray Crystal Structure of Canine Myeloperoxidase at 3 Angstroms Resolution

Zeng, J.,Fenna, R.E.
(1992)  J.Mol.Biol.  226 : 185

Reaction

Chain : A, B
UniProt : P05979 (PGH1_SHEEP)
Reaction: EC: Evidence:
Physiological Direction:
(5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + 2 O2 = A + H2O + prostaglandin H2 1.14.99.1 PubMed:7947975
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(5Z,8Z,11Z,14Z)-eicosatetraenoate + 2 O2 = prostaglandin G2 - PubMed:7947975
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AH2 + prostaglandin G2 = A + H2O + prostaglandin H2 - PubMed:7947975
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(9Z,12Z)-octadecadienoate + AH2 + O2 = (9R)-hydroxy-(10E,12Z)- octadecadienoate + A + H2O - PubMed:9448728
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(9Z,12Z)-octadecadienoate + AH2 + O2 = (9S)-hydroxy-(10E,12Z)- octadecadienoate + A + H2O - PubMed:9448728
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(9Z,12Z)-octadecadienoate + AH2 + O2 = (13S)-hydroxy-(9Z,11E)- octadecadienoate + A + H2O - PubMed:9448728
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(9Z,12Z)-octadecadienoate + AH2 + O2 = (13R)-hydroxy-(9Z,11E)- octadecadienoate + A + H2O - PubMed:9448728
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