Brand  (β version)

PDB ID: 1CPX

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Ligands
Code Name Style Show Link
OH Hydroxide ion PoSSuM
ZN Zinc ion PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 1CPX   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : BETA FORM OF CARBOXYPEPTIDASE A (RESIDUES 3-307) FROM BOVINE PANCREAS IN AN ORTHORHOMBIC CRYSTAL FORM WITH TWO ZINC IONS IN THE ACTIVE SITE.
Release Data : 1998-08-05
Compound :
mol_id molecule chains synonym
1 PROTEIN (CARBOXYPEPTIDASE A) A CPA, BETA FORM
ec: 3.4.17.1
other_details: TRUNCATED FORM OF CPA (RESIDUES 3-307 I.E. THE BETA FORM) INDUCED BY TRACES OF TRYPSIN
Source :
mol_id organism_scientific organism_common
1 Bos taurus  (taxid:9913) Cattle
organ: PANCREAS
other_details: SIGMA #C0261; COX ET AL. (1964) BIOCHEMISTRY 3, 44-47
Authors : Bukrinsky, J.T., Bjerrum, M.J., Kadziola, A.
Keywords : METALLOPROTEASE, HYDROLASE, CARBOXYPEPTIDASE, ZINC INHIBITION, INDUCED FIT
Exp. method : X-RAY DIFFRACTION ( 2.00 Å )
Citation :

Native carboxypeptidase A in a new crystal environment reveals a different conformation of the important tyrosine 248.

Bukrinsky, J.T.,Bjerrum, M.J.,Kadziola, A.
(1998)  Biochemistry  37 : 16555 - 16564

PubMed: 9843422
DOI: 10.1021/bi981678i

Reaction

Chain : A
UniProt : P00730 (CBPA1_BOVIN)
Reaction: EC: Evidence:
Physiological Direction:
Release of a C-terminal amino acid, but little or no action with -Asp, -Glu, -Arg, -Lys or -Pro. 3.4.17.1 UniProtKB:P15085
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H2O + leukotriene C4 = glycine + leukotriene F4 - PubMed:12729612
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