Het-PDB Navi2 (PDB: 1CMK)

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Ligands
Code	Name		Style	Show	Link
IOD	Iodide ion				PoSSuM
MYR	Myristic acid				PoSSuM

Non-standard Residues
Code	Name	Show
SEP	Phosphoserine
TPO	Phosphothreonine

Glycosylation
Code	Name	Emphasize

Modification
Code	Name	Show

Download interaction data: 1CMK

Code :

1CMK PDBj RCSB PDB PDBe

Header :

TRANSFERASE/TRANSFERASE INHIBITOR

Title :

CRYSTAL STRUCTURES OF THE MYRISTYLATED CATALYTIC SUBUNIT OF CAMP-DEPENDENT PROTEIN KINASE REVEAL OPEN AND CLOSED CONFORMATIONS

Release Data :

1994-05-31

Compound :

mol_id	molecule	chains
1	cAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT	E
	ec: 2.7.11.11

mol_id	molecule	chains
2	cAMP-dependent protein kinase inhibitor, alpha form	I

Source :

mol_id	organism_scientific	organism_common
1	Sus scrofa (taxid:9823)	Pig
	organ: HEART

mol_id	organism_scientific	organism_common
2	Homo sapiens (taxid:9606)	Human
	synthetic: yes

Authors :

Zheng, J., Knighton, D.R., Xuong, N.-H., Taylor, S.S., Sowadski, J.M., Ten Eyck, L.F.

Keywords :

PHOSPHOTRANSFERASE, transferase-transferase inhibitor complex

Exp. method :

X-RAY DIFFRACTION ( 2.9 Å )

Citation :

Crystal structures of the myristylated catalytic subunit of cAMP-dependent protein kinase reveal open and closed conformations.

Zheng, J.,Knighton, D.R.,Xuong, N.H. et al.
(1993) Protein Sci. 2 : 1559 - 1573

PubMed: 8251932

The Crystal Structure of the Mammalian Catalytic Subunit of Camp-Dependent Protein Kinase and a Di-Iodinated Pki(5-24) Inhibitor Peptide Displays an Open Conformation

Karlsson, R.,Zheng, J.,Xuong, N.-H. et al.
(1993) Acta Crystallogr.,Sect.D 49 : 381

2.2 Angstroms Refined Crystal Structure of the Catalytic Subunit of Camp-Dependent Protein Kinase Complexed with Mnatp and a Peptide Inhibitor

Zheng, J.,Trafny, E.A.,Knighton, D.R. et al.
(1993) Acta Crystallogr.,Sect.D 49 : 362

Crystal Structure of the Catalytic Subunit of Camp-Dependent Protein Kinase Complexed with Mgatp and Peptide Inhibitor

Zheng, J.,Knighton, D.R.,Ten Eyck, L.F. et al.
(1993) Biochemistry 32 : 2154

Structure of a Peptide Inhibitor Bound to the Catalytic Subunit of Cyclic Adenosine Monophosphate-Dependent Protein Kinase

Knighton, D.R.,Zheng, J.,Ten Eyck, L.F. et al.
(1991) Science 253 : 414

Crystal Structure of the Catalytic Subunit of Camp-Dependent Protein Kinase

Knighton, D.R.,Zheng, J.,Ten Eyck, L.F. et al.
(1991) Science 253 : 407

Expression of the Catalytic Subunit of Camp-Dependent Protein Kinase in Escherichia Coli

Slice, L.W.,Taylor, S.S.
(1989) J.Biol.Chem. 264 : 20940

Differential Labeling and Identification of the Cysteine-Containing Tryptic Peptides of Catalytic Subunit from Porcine Heart Camp-Dependent Protein Kinase

Nelson, N.C.,Taylor, S.S.
(1981) J.Biol.Chem. 256 : 3743

Chain :

UniProt :

P00517 (KAPCA_BOVIN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]	2.7.11.11	-
	-	-
ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]	2.7.11.11	-
	-	-

Chain :	I
UniProt :	P61925 (IPKA_HUMAN)
Reaction :	-

PDB ID: 1CMK

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