Het-PDB Navi2 (PDB: 1CM0)

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Ligands
Code	Name		Style	Show	Link
COA	Coenzyme a				PoSSuM

Non-standard Residues
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Glycosylation
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Download interaction data: 1CM0

Code :

1CM0 PDBj RCSB PDB PDBe

Header :

SIGNALING PROTEIN

Title :

CRYSTAL STRUCTURE OF THE PCAF/COENZYME-A COMPLEX

Release Data :

1999-07-06

Compound :

mol_id	molecule	chains
1	P300/CBP ASSOCIATING FACTOR	B,A
	fragment: HISTONE ACETYLTRANSFERASE DOMAIN other_details: COCRYSTALLIZED WITH COENZYME A

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli BL21(DE3) (taxid:469008)
	cellular_location: NUCLEUS expression_system_strain: BL21(DE3) expression_system_cellular_location: CYTOPLASM expression_system_vector_type: PLASMID expression_system_plasmid: PRSET A

Authors :

Clements, A., Rojas, J.R., Trievel, R.C., Wang, L., Berger, S.L., Marmorstein, R.

Keywords :

P300/CBP ASSOCIATED FACTOR, COENZYME A, ACETYLTRANSFERASE, COACTIVATOR, SIGNALING PROTEIN

Exp. method :

X-RAY DIFFRACTION ( 2.3 Å )

Citation :

Crystal structure of the histone acetyltransferase domain of the human PCAF transcriptional regulator bound to coenzyme A.

Clements, A.,Rojas, J.R.,Trievel, R.C. et al.
(1999) EMBO J. 18 : 3521 - 3532

Chain :

B, A

UniProt :

Q92831 (KAT2B_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
acetyl-CoA + L-lysyl-[protein] = CoA + H(+) + N(6)-acetyl-L- lysyl-[protein]	2.3.1.48	PubMed:23001180, PubMed:27389534, PubMed:8945521
	left-to-right	PubMed:23001180, PubMed:27389534
acetyl-CoA + spermidine = CoA + H(+) + N(8)-acetylspermidine	2.3.1.57	PubMed:27389534
	left-to-right	PubMed:27389534

PDB ID: 1CM0