Brand  (β version)

color scheme of protein:

hetatm:

x
information
centroid:
interaction residue:

chain:

Ligands
Code Name Link
EDO 1,2-ethanediol
PVB Purvalanol B
Code : 1CKP   PDBj   RCSB PDB   PDBe
Header : HORMONE/GROWTH FACTOR
Title : HUMAN CYCLIN DEPENDENT KINASE 2 COMPLEXED WITH THE INHIBITOR PURVALANOL B
Release Data : 1999-01-13
Compound :
mol_id molecule chains synonym
1 PROTEIN (CYCLIN-DEPENDENT PROTEIN KINASE 2) A CDK2
ec: 2.7.1.37
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Spodoptera frugiperda  (taxid:7108)
cell_line: SF9
expression_system_common: Fall armyworm
expression_system_cell_line: SF9
expression_system_vector: BACULOVIRUS
Authors : Gray, N.S., Thunnissen, A.M.W.H., Schultz, P.G., Kim, S.H.
Keywords : PROTEIN KINASE, CELL CYCLE, PHOSPHORYLATION, CELL DIVISION, MITOSIS, INHIBITION, HORMONE-GROWTH FACTOR COMPLEX
Exp. method : X-RAY DIFFRACTION ( 2.05 Å )
Citation :

Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors.

Gray, N.S.,Wodicka, L.,Thunnissen, A.M.  et al.
(1998)  Science  281 : 533 - 538

PubMed: 9677190
DOI: 10.1126/science.281.5376.533

Inhibition of Cyclin-Dependent Kinases by Purine Analogues-Crystal Structure of Human Cdk2 Complexed with Roscovitine

De Azevedo, W.F.,Leclerc, S.,Meijer, L.  et al.
(1997)  Eur.J.Biochem.  243 : 518

Multiple Modes of Ligand Recognition: Crystal Structures of Cyclin-Dependent Protein Kinase 2 in Complex with ATP and Two Inhibitors, Olomoucine and Isopentenyladenine

Schultze-Gahmen, U.,Brandsen, J.,Jones, H.D.  et al.
(1995)  Protein Sci.  22 : 378

Crystal Structure of Cyclin-Dependent Kinase 2

De Bondt, H.L.,Rosenblatt, J.,Jancarik, J.  et al.
(1993)  Nature  363 : 595

Chain : A
UniProt : P24941 (CDK2_HUMAN)
Reaction : ATP + a protein = ADP + a phosphoprotein.