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Ligands
Code Name Style Show Link
CL Chloride ion
DAD 2',3'-dideoxyadenosine-5'-triphosphate
FOK Forskolin
GSP 5'-guanosine-diphosphate-monothiophosphate
MG Magnesium ion
Non-standard Residues
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Glycosylation
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Code : 1CJU   PDBj   RCSB PDB   PDBe
Header : LYASE/LYASE/SIGNALING PROTEIN
Title : COMPLEX OF GS-ALPHA WITH THE CATALYTIC DOMAINS OF MAMMALIAN ADENYLYL CYCLASE: COMPLEX WITH BETA-L-2',3'-DIDEOXYATP AND MG
Release Data : 1999-08-31
Compound :
mol_id molecule chains synonym
1 ADENYLATE CYCLASE, TYPE V A PROTEIN VC1
ec: 4.6.1.1
fragment: C1A DOMAIN OF ADENYLYL CYCLASE
mutation: V476M
mol_id molecule chains synonym
2 ADENYLATE CYCLASE, TYPE II B PROTEIN IIC2, ATP PYROPHOSPHATE-LYASE, ADENYLYL CYCLASE
ec: 4.6.1.1
fragment: C2A DOMAIN OF ADENYLYL CYCLASE
mol_id molecule chains synonym
3 GUANINE NUCLEOTIDE-BINDING PROTEIN G(S) C ALPHA SUBUNIT OF ADENYLATE CYCLASE-STIMULATING G ALPHA PROTEIN, GS-ALPHA, PROTEIN GSA
fragment: TRYPSINIZED FRAGMENT
mutation: N-TERMINAL HEXAHISTIDINE TAG
Source :
mol_id organism_scientific organism_common expression_system
1 Canis lupus  (taxid:9615) Dog Escherichia coli BL21(DE3)  (taxid:469008)
strain: familiaris
organ: CARDIAC MUSCLE
cellular_location: CYTOPLASM
gene: ADENYLYL CYCLASE TYPE V
expression_system_strain: BL21
expression_system_variant: DE3
expression_system_vector_type: MULTI-COPY PLASMID
expression_system_plasmid: PQE60-H6-VC1(580)
mol_id organism_scientific organism_common expression_system
2 Rattus norvegicus  (taxid:10116) Norway rat Escherichia coli BL21(DE3)  (taxid:469008)
organ: BRAIN
cellular_location: CYTOPLASM
gene: ADENYLYL CYCLASE TYPE II
expression_system_strain: BL21
expression_system_variant: DE3
expression_system_vector_type: MULTI-COPY PLASMID
expression_system_plasmid: PQE60-ARGC-IIC2
mol_id organism_scientific organism_common expression_system
3 Bos taurus  (taxid:9913) Cattle Escherichia coli BL21(DE3)  (taxid:469008)
cellular_location: CYTOPLASM
gene: GNAS
expression_system_strain: BL21
expression_system_variant: DE3
expression_system_vector_type: MULTI-COPY PLASMID
expression_system_plasmid: PQE60-GSALPHA-H
expression_system_gene: GNAS
Authors : Tesmer, J.J.G., Sprang, S.R.
Keywords : COMPLEX (LYASE-HYDROLASE), HYDROLASE, SIGNAL TRANSDUCING PROTEIN, CYCLASE, EFFECTOR ENZYME, LYASE-LYASE-SIGNALING PROTEIN COMPLEX
Exp. method : X-RAY DIFFRACTION ( 2.80 Å )
Citation :

Two-metal-Ion catalysis in adenylyl cyclase.

Tesmer, J.J.,Sunahara, R.K.,Johnson, R.A.  et al.
(1999)  Science  285 : 756 - 760

PubMed: 10427002
DOI: 10.1126/science.285.5428.756

Crystal Structure of the Catalytic Domains of Adenylyl Cyclase in a Complex with Gsalpha(Dot)Gtpgammas

Tesmer, J.J.,Sunahara, R.K.,Gilman, A.G.  et al.
(1997)  Science  278 : 1907

DOI: 10.1126/science.278.5345.1907

Chain : A
UniProt : P30803 (ADCY5_CANLF)
Reaction: EC: Evidence:
Physiological Direction:
ATP = 3',5'-cyclic AMP + diphosphate 4.6.1.1 PubMed:10427002, PubMed:11087399, PubMed:15591060, PubMed:1618857, PubMed:16766715, PubMed:19243146, PubMed:8428899
-
Chain : B
UniProt : P26769 (ADCY2_RAT)
Reaction: EC: Evidence:
Physiological Direction:
ATP = 3',5'-cyclic AMP + diphosphate 4.6.1.1 PubMed:10427002, PubMed:11087399, PubMed:15591060, PubMed:16766715, PubMed:1719547, PubMed:19243146, PubMed:21596131, PubMed:22906005, PubMed:24363043, PubMed:7761832
-
Chain : C
UniProt : P04896 (GNAS2_BOVIN)
Reaction : -