Brand  (β version)

PDB ID: 1CJB

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Ligands
Code Name Style Show Link
MG Magnesium ion PoSSuM
IRP (1s)-1(9-deazahypoxanthin-9yl)1,4-dideoxy-1,4-imino-D-ribitol-5-phosphate PoSSuM
POP Pyrophosphate 2- PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 1CJB   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : MALARIAL PURINE PHOSPHORIBOSYLTRANSFERASE
Release Data : 1999-08-18
Compound :
mol_id molecule chains
1 PROTEIN (HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE) A,B,C,D
ec: 2.4.2.8
Source :
mol_id organism_scientific organism_common expression_system
1 Plasmodium falciparum  (taxid:5833) Malaria parasite P. falciparum Escherichia coli  (taxid:562)
Authors : Shi, W., Li, C.M., Tyler, P.C., Furneaux, R.H., Cahill, S.M., Girvin, M.E., Grubmeyer, C., Schramm, V.L., Almo, S.C.
Keywords : MALARIA, PURINE SALVAGE, PHOSPHORIBOSYLTRANSFERASE, TRANSITION STATE INHIBITOR, TRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 2.00 Å )
Citation :

The 2.0 A structure of malarial purine phosphoribosyltransferase in complex with a transition-state analogue inhibitor.

Shi, W.,Li, C.M.,Tyler, P.C.  et al.
(1999)  Biochemistry  38 : 9872 - 9880

PubMed: 10433693
DOI: 10.1021/bi990664p

Reaction

Chain : A, B, C, D
UniProt : P20035 (HGXR_PLAFG)
Reaction: EC: Evidence:
Physiological Direction:
diphosphate + IMP = 5-phospho-alpha-D-ribose 1-diphosphate + hypoxanthine 2.4.2.8 UniProtKB:Q26997
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diphosphate + GMP = 5-phospho-alpha-D-ribose 1-diphosphate + guanine 2.4.2.8 UniProtKB:Q26997
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diphosphate + XMP = 5-phospho-alpha-D-ribose 1-diphosphate + xanthine 2.4.2.22 UniProtKB:Q26997
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