Brand  (β version)

PDB ID: 1CJ1

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Ligands
Code Name Style Show Link
C78 [1-[1-(6-carbamoyl-cyclohex-2-enylcarbamoyl)-cyclohexylcarbamoyl]-2-(4-phosphonooxy-phenyl)- ethyl]-carbamic acid 3-aminobenzylester PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 1CJ1   PDBj   RCSB PDB   PDBe
Header : SIGNALING PROTEIN
Title : GROWTH FACTOR RECEPTOR BINDING PROTEIN SH2 DOMAIN (HUMAN) COMPLEXED WITH A PHOSPHOTYROSYL DERIVATIVE
Release Data : 1999-12-22
Compound :
mol_id molecule chains synonym
1 PROTEIN (GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2) A,B,C,D,E,F,G,H,I,J,K,L GRB2-SH2
fragment: SH2 DOMAIN
other_details: COMPLEXED WITH PHOSPHOTYROSYL DERIVATIVE
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
Authors : Rahuel, J.
Keywords : SIGNAL TRANSDUCTION, SH2 DOMAIN, PHOSPHOTYROSINE, SIGNALING PROTEIN
Exp. method : X-RAY DIFFRACTION ( 3.0 Å )
Citation :

Structure-based design, synthesis, and X-ray crystallography of a high-affinity antagonist of the Grb2-SH2 domain containing an asparagine mimetic.

Furet, P.,Garcia-Echeverria, C.,Gay, B.  et al.
(1999)  J.Med.Chem.  42 : 2358 - 2363

PubMed: 10395476
DOI: 10.1021/jm991013u

Reaction

Chain : A, B, C, D, E, F, G, H, I, J, K, L
UniProt : P62993 (GRB2_HUMAN)
Reaction : -