Het-PDB Navi2 (PDB: 1CI7)

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Ligands
Code	Name		Style	Show	Link
CB3	10-propargyl-5,8-dideazafolic acid				PoSSuM
UMP	2'-deoxyuridine 5'-monophosphate				PoSSuM

Non-standard Residues
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Glycosylation
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Download interaction data: 1CI7

Code :

1CI7 PDBj RCSB PDB PDBe

Header :

TRANSFERASE

Title :

TERNARY COMPLEX OF THYMIDYLATE SYNTHASE FROM PNEUMOCYSTIS CARINII

Release Data :

2000-04-10

Compound :

mol_id	molecule	chains
1	PROTEIN (THYMIDYLATE SYNTHASE)	A,B
	ec: 2.1.1.45 other_details: COVALENT BOND BETWEEN C173 AND DUMP IN MONOMER A

Source :

mol_id	organism_scientific	expression_system
1	Pneumocystis carinii (taxid:4754)	Escherichia coli (taxid:562)
	cellular_location: CYTOPLASM expression_system_strain: CHI2913 expression_system_cellular_location: CYTOPLASM expression_system_vector_type: PLASMID expression_system_plasmid: PUETS-1.8

Authors :

Anderson, A.C., O'Neil, R.H., Delano, W.L., Stroud, R.M.

Keywords :

METHYLTRANSFERASE, NUCLEOTIDE BIOSYNTHESIS, HALF-SITES REACTIVITY, TRANSFERASE

Exp. method :

X-RAY DIFFRACTION ( 2.6 Å )

Citation :

The structural mechanism for half-the-sites reactivity in an enzyme, thymidylate synthase, involves a relay of changes between subunits.

Anderson, A.C.,O'Neil, R.H.,DeLano, W.L. et al.
(1999) Biochemistry 38 : 13829 - 13836

Chain :

A, B

UniProt :

P13100 (TYSY_PNECA)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dUMP = 7,8- dihydrofolate + dTMP	2.1.1.45	-
	-	-

PDB ID: 1CI7