Brand  (β version)

PDB ID: 1CFJ

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Ligands
Code Name Style Show Link
GB Methylphosphonic acid ester group PoSSuM
Non-standard Residues
Code Name Show
Glycosylation
Code Name Emphasize
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose
Modification
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Structure summary

Code : 1CFJ   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : METHYLPHOSPHONYLATED ACETYLCHOLINESTERASE (AGED) OBTAINED BY REACTION WITH O-ISOPROPYLMETHYLPHOSPHONOFLUORIDATE (GB, SARIN)
Release Data : 1999-06-25
Compound :
mol_id molecule chains
1 PROTEIN (ACETYLCHOLINESTERASE) A
ec: 3.1.1.7
Source :
mol_id organism_scientific organism_common
1 Torpedo californica  (taxid:7787) Pacific electric ray
organ: ELECTRIC ORGAN
tissue: ELECTROPLAQUE
cellular_location: MEMBRANE BOUND BY GPI ANCHOR
Authors : Millard, C.B., Silman, I., Sussman, J.L.
Keywords : CHOLINESTERASE, ORGANOPHOSPHATE, SERINE HYDROLASE, CHEMICAL-WARFARE, HYDROLASE
Exp. method : X-RAY DIFFRACTION ( 2.60 Å )
Citation :

Crystal structures of aged phosphonylated acetylcholinesterase: nerve agent reaction products at the atomic level.

Millard, C.B.,Kryger, G.,Ordentlich, A.  et al.
(1999)  Biochemistry  38 : 7032 - 7039

PubMed: 10353814
DOI: 10.1021/bi982678l

Crystal Structural of "Aged" Phosphorylated and Phosphonylated torpedo californica Acetylcholinesterase

Millard, C.B.,Kryger, G.,Ordentlich, A.  et al.
(1998)  Structure and Function of Cholinesterases and Related Proteins  : 425

Reaction

Chain : A
UniProt : P04058 (ACES_TETCF)
Reaction: EC: Evidence:
Physiological Direction:
acetylcholine + H2O = acetate + choline + H(+) 3.1.1.7 -
-