Brand  (β version)

PDB ID: 1CF4

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Ligands
Code Name Style Show Link
GNP Phosphoaminophosphonic acid-guanylate ester PoSSuM
MG Magnesium ion PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 1CF4   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : CDC42/ACK GTPASE-BINDING DOMAIN COMPLEX
Release Data : 1999-06-18
Compound :
mol_id molecule chains
1 PROTEIN (CDC42 HOMOLOG) A
mutation: Q61L
mol_id molecule chains
2 PROTEIN (ACTIVATED P21CDC42HS KINASE) B
fragment: GTPASE-BINDING DOMAIN
other_details: COMPLEXED WITH 5'-GUANOSYL-IMIDO-TRIPHOSPHATE
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
mol_id organism_scientific organism_common
2 Homo sapiens  (taxid:9606) Human
Authors : Mott, H.R., Owen, D., Nietlispach, D., Lowe, P.N., Lim, L., Laue, E.D.
Keywords : CDC42-ACK GTPASE COMPLEX, G PROTEIN, TRANSFERASE
Exp. method : SOLUTION NMR
Citation :

Structure of the small G protein Cdc42 bound to the GTPase-binding domain of ACK.

Mott, H.R.,Owen, D.,Nietlispach, D.  et al.
(1999)  Nature  399 : 384 - 388

PubMed: 10360579
DOI: 10.1038/20732

Reaction

Chain : A
UniProt : P60953 (CDC42_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
GTP + H2O = GDP + H(+) + phosphate 3.6.5.2 PubMed:21565175, PubMed:23940119
left-to-right
Chain : B
UniProt : Q07912 (ACK1_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein] 2.7.10.2 PROSITE-ProRule:PRU10028, PubMed:10652228, PubMed:16257963, PubMed:16472662, PubMed:18993068, PubMed:20333297
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ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein] 2.7.11.1 PubMed:16257963, PubMed:18993068
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ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein] 2.7.11.1 PubMed:16257963, PubMed:18993068
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