Het-PDB Navi2 (PDB: 1CDK)

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Ligands
Code	Name	Link
MN	Manganese (II) ion	PoSSuM
ANP	Phosphoaminophosphonic acid-adenylate ester	PoSSuM
MYR	Myristic acid	PoSSuM

Non-standard Residues
Code	Name	Show
TPO	Phosphothreonine

Glycosylation
Code	Name	Emphasize

Modification
Code	Name	Show

Download interaction data: 1CDK

Code :

1CDK PDBj RCSB PDB PDBe

Header :

TRANSFERASE/TRANSFERASE INHIBITOR

Title :

CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT (E.C.2.7.1.37) (PROTEIN KINASE A) COMPLEXED WITH PROTEIN KINASE INHIBITOR PEPTIDE FRAGMENT 5-24 (PKI(5-24) ISOELECTRIC VARIANT CA) AND MN2+ ADENYLYL IMIDODIPHOSPHATE (MNAMP-PNP) AT PH 5.6 AND 7C AND 4C

Release Data :

1995-10-15

Compound :

mol_id	molecule	chains	synonym
1	CAMP-DEPENDENT PROTEIN KINASE	A,B	PROTEIN KINASE A
	ec: 2.7.11.11

mol_id	molecule	chains	synonym
2	PROTEIN KINASE INHIBITOR	I,J	PKI(5-24)

Source :

mol_id	organism_scientific	organism_common
1	Sus scrofa (taxid:9823)	Pig
	organ: HEART tissue: HEART ISOFORM CA

mol_id	organism_scientific	organism_common
2	Homo sapiens (taxid:9606)	Human
	synthetic: yes

Authors :

Bossemeyer, D., Engh, R.A., Kinzel, V., Ponstingl, H., Huber, R.

Keywords :

COMPLEX (TRANSFERASE-INHIBITOR), TRANSFERASE-TRANSFERASE INHIBITOR complex

Exp. method :

X-RAY DIFFRACTION ( 2.0 Å )

Citation :

Phosphotransferase and substrate binding mechanism of the cAMP-dependent protein kinase catalytic subunit from porcine heart as deduced from the 2.0 A structure of the complex with Mn2+ adenylyl imidodiphosphate and inhibitor peptide PKI(5-24).

Bossemeyer, D.,Engh, R.A.,Kinzel, V. et al.
(1993) EMBO J. 12 : 849 - 859

PubMed: 8384554

2.2 Angstrom Refined Crystal Structure of the Catalytic Subunit of cAMP-Dependent Protein Kinase Complexed with Mnatp and a Peptide Inhibitor

Zheng, J.,Trafny, E.A.,Knighton, D.R. et al.
(1993) Acta Crystallogr.,Sect.D 49 : 362

Crystal Structures of the Myristylated Catalytic Subunit Ofcamp-Dependent Kinase Reveal Open and Closed Conformation

Zheng, J.,Knighton, D.R.,Xuong, N.-H. et al.
(1993) Protein Sci. 2 : 1559

Crystal Structure of the Catalytic Subunit of Cyclic Adenosine Monophosphate Dependent-Protein Kinase

Knighton, D.R.,Zheng, J.H.,Ten Eyck, L.F. et al.
(1991) Science 253 : 407

Structure of a Peptide Inhibitor Bound to the Catalytic Subunit of a Cyclic Adenosine Monophosphate-Dependent Protein Kinase

Knighton, D.R.,Zheng, J.,Ten Eyck, L.F. et al.
(1991) Science 253 : 414

Regulation by Phosphorylation of Reversible Association of a Myristoylated Protein Kinase C Substrate with the Plasma Membrane

Thelen, M.,Rosen, A.,Nairn, A.C. et al.
(1991) Nature 351 : 320

A Sequence Variant in the N-Terminal Region of the Catalytic Subunit of the cAMP-Dependent Protein Kinase

Hotz, A.,Konig, N.,Kretschmer, J. et al.
(1989) FEBS Lett. 256 : 115

Characterization of Genomic Clones Coding for the C-Alpha and C-Beta Subunits of Mouse Camp Dependent Protein Kinase

Chrivia, J.C.,Uhler, M.D.,Mcknight, G.S.
(1988) J.Biol.Chem. 263 : 5739

Chain :

A, B

UniProt :

P00517 (KAPCA_BOVIN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]	2.7.11.11	-
	-	-
ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]	2.7.11.11	-
	-	-

Chain :	I, J
UniProt :	P61925 (IPKA_HUMAN)
Reaction :	-

PDB ID: 1CDK

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