Brand  (β version)

PDB ID: 1CAQ

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Ligands
Code Name Style Show Link
ZN Zinc ion PoSSuM
CA Calcium ion PoSSuM
SO4 Sulfate ion PoSSuM
DPS 3-(1h-indol-3-yl)-2-[4-(4-phenyl-piperidin-1-yl)-benzenesulfonylamino]-propionic acid PoSSuM
Non-standard Residues
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Structure summary

Code : 1CAQ   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : X-RAY STRUCTURE OF HUMAN STROMELYSIN CATALYTIC DOMAIN COMPLEXES WITH NON-PEPTIDE INHIBITORS: IMPLICATION FOR INHIBITOR SELECTIVITY
Release Data : 1999-07-07
Compound :
mol_id molecule chains synonym
1 PROTEIN (STROMELYSIN-1) A MATRIX METALLOPROTEINASE-3
ec: 3.4.24.17
fragment: CATALYTIC DOMAIN
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
cell_line: FIBROBLAST
expression_system_plasmid: PGEMEX-1
Authors : Pavlovsky, A.G., Williams, M.G., Ye, Q.-Z., Ortwine, D.F., Purchase II, C.F., White, A.D., Dhanaraj, V., Roth, B.D., Johnson, L.L., Hupe, D., Humblet, C., Blundell, T.L.
Keywords : MATRIX METALLOPROTEINASE, MMP-3, NON-PEPTIDE INHIBITOR, HYDROLASE
Exp. method : X-RAY DIFFRACTION ( 1.8 Å )
Citation :

X-ray structure of human stromelysin catalytic domain complexed with nonpeptide inhibitors: implications for inhibitor selectivity.

Pavlovsky, A.G.,Williams, M.G.,Ye, Q.Z.  et al.
(1999)  Protein Sci.  8 : 1455 - 1462

PubMed: 10422833

Reaction

Chain : A
UniProt : P08254 (MMP3_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
Preferential cleavage where P1', P2' and P3' are hydrophobic residues. 3.4.24.17 PubMed:1371271, PubMed:21330369
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