Het-PDB Navi2 (PDB: 1CA8)

The number of atoms exceeds 100,000.
So, it can not be displayed here.

Select unit:

Select hetatm:

information

centroid:

interaction residue:

Select chain: Sequence Hide other chain(s)

Data format:

Color scheme of protein:

Ligands
Code	Name		Style	Show	Link
0KV	2-{(3s)-3-[(benzylsulfonyl)amino]-2-oxopiperidin-1-yl}-N-{(2s)-1-[(3s)-1-carbamimidoylpiperidin-3-yl]-3-oxopropan-2-yl}acetamide				PoSSuM
NA	Sodium ion				PoSSuM

Non-standard Residues
Code	Name	Show
TYS	O-sulfo-L-tyrosine

Glycosylation
Code	Name	Emphasize

Modification
Code	Name	Show
ACE	Acetyl group

Download interaction data: 1CA8

Code :

1CA8 PDBj RCSB PDB PDBe

Header :

HYDROLASE/HYDROLASE INHIBITOR

Title :

Thrombin inhibitors with rigid tripeptidyl aldehydes

Release Data :

1999-04-27

Compound :

mol_id	molecule	chains
1	Thrombin light chain	A
	ec: 3.4.21.5 fragment: Peptidase S1 domain

mol_id	molecule	chains
2	Thrombin heavy chain	B
	ec: 3.4.21.5

mol_id	molecule	chains
3	HIRUGEN	C

Source :

mol_id	organism_scientific	organism_common
1	Homo sapiens (taxid:9606)	Human
	tissue: BLOOD

mol_id	organism_scientific	organism_common
2	Homo sapiens (taxid:9606)	Human
	tissue: BLOOD

mol_id	organism_scientific	organism_common
3	Hirudo medicinalis (taxid:6421)	Medicinal leech

Authors :

Krishnan, R., Zhang, E., Hakansson, K., Arni, R.K., Tulinsky, A., Lim-Wilby, M.S.L., Levy, O.E., Semple, J.E., Brunck, T.K.

Keywords :

SERINE PROTEASE, HYDROLASE-HYDROLASE INHIBITOR complex

Exp. method :

X-RAY DIFFRACTION ( 2.1 Å )

Citation :

Highly selective mechanism-based thrombin inhibitors: structures of thrombin and trypsin inhibited with rigid peptidyl aldehydes

Krishnan, R.,Zhang, E.,Hakansson, K. et al.
(1998) Biochemistry 37 : 12094 - 12103

Chain :

UniProt :

P00734 (THRB_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
Selective cleavage of Arg-\|-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B.	3.4.21.5	-
	-	-

PDB ID: 1CA8