Brand  (β version)

PDB ID: 1C8L

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Ligands
Code Name Style Show Link
BIN 2,3-dicarboxy-4-(2-chloro-phenyl)-1-ethyl-5-isopropoxycarbonyl-6-methyl-pyridinium PoSSuM
CFF Caffeine PoSSuM
GOL Glycerol PoSSuM
PLP Pyridoxal-5'-phosphate PoSSuM
Non-standard Residues
Code Name Show
SEP Phosphoserine
Glycosylation
Code Name Emphasize
Modification
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Structure summary

Code : 1C8L   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : SYNERGISTIC INHIBITION OF GLYCOGEN PHOSPHORYLASE A BY A POTENTIAL ANTIDIABETIC DRUG AND CAFFEINE
Release Data : 2000-05-31
Compound :
mol_id molecule chains
1 PROTEIN (GLYCOGEN PHOSPHORYLASE) A
ec: 2.4.1.1
Source :
mol_id organism_scientific organism_common
1 Oryctolagus cuniculus  (taxid:9986) Rabbit
tissue: MUSCLE
Authors : Tsitsanou, K.E., Skamnaki, V.T., Oikonomakos, N.G.
Keywords : GLYCOGEN METABOLISM, DIABETES, PHOSPHORYLASE A, SYNERGISTIC INHIBITION, ALLOSTERIC SITE, INHIBITOR SITE, TRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 2.30 Å )
Citation :

Structural basis of the synergistic inhibition of glycogen phosphorylase a by caffeine and a potential antidiabetic drug.

Tsitsanou, K.E.,Skamnaki, V.T.,Oikonomakos, N.G.
(2000)  Arch.Biochem.Biophys.  384 : 245 - 254

PubMed: 11368311
DOI: 10.1006/abbi.2000.2121

Allosteric Inhibition of Glycogen Phosphorylase a by the Potential Antidiabetic Drug 3-Isopropyl 4-(2-Chlorophenyl)-1,4-Dihydro-1-Ethyl-2-Methyl-Pyridine-3,5,6-Tricarboxylate

Oikonomakos, N.G.,Tsitsanou, K.E.,Zographos, S.E.  et al.
(1999)  Protein Sci.  8 : 1930 - 1945

The Structure of Glycogen Phosphorylase B with an Alkyl-Dihydropyridine-Dicarboxylic Acid Compound, a Novel and Potent Inhibitor

Zographos, S.E.,Oikonomakos, N.G.,Tsitsanou, K.E.  et al.
(1997)  Structure  5 : 1413 - 1425

DOI: 10.1016/S0969-2126(97)00292-X

Reaction

Chain : A
UniProt : P00489 (PYGM_RABIT)
Reaction: EC: Evidence:
Physiological Direction:
[(1->4)-alpha-D-glucosyl](n) + phosphate = [(1->4)-alpha-D- glucosyl](n-1) + alpha-D-glucose 1-phosphate 2.4.1.1 UniProtKB:P11217
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