Brand  (β version)

PDB ID: 1C8K

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Ligands
Code Name Style Show Link
CPB 2-(2-chloro-phenyl)-5,7-dihydroxy-8-(3-hydroxy-1-methyl-piperidin-4-yl)-4h-benzopyran-4-one PoSSuM
PLP Pyridoxal-5'-phosphate PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 1C8K   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : FLAVOPIRIDOL INHIBITS GLYCOGEN PHOSPHORYLASE BY BINDING AT THE INHIBITOR SITE
Release Data : 2000-05-24
Compound :
mol_id molecule chains
1 PROTEIN (GLYCOGEN PHOSPHORYLASE) A
ec: 2.4.1.1
Source :
mol_id organism_scientific organism_common
1 Oryctolagus cuniculus  (taxid:9986) Rabbit
tissue: MUSCLE
Authors : Oikonomakos, N.G., Zographos, S.E., Skamnaki, V.T., Tsitsanou, K.E., Johnson, L.N.
Keywords : GLYCOGEN METABOLISM, GLYCOGEN PHOSPHORYLASE B, INHIBITION, INHIBITOR BINDING SITE, ANTITUMOUR AGENT, TRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 1.76 Å )
Citation :

Flavopiridol inhibits glycogen phosphorylase by binding at the inhibitor site.

Oikonomakos, N.G.,Schnier, J.B.,Zographos, S.E.  et al.
(2000)  J.Biol.Chem.  275 : 34566 - 34573

PubMed: 10924512
DOI: 10.1074/jbc.M004485200

Allosteric Inhibition of Glycogen Phosphorylase a by the Potential Antidiabetic Drug 3-Isopropyl 4-(2-Chlorophenyl)-1,4-Dihydro-1-Ethyl-2-Methyl-Pyridine-3,5,6-Tricarboxylate

Oikonomakos, N.G.,Tsitsanou, K.E.,Zographos, S.E.  et al.
(1999)  Protein Sci.  8 : 1930 - 1935

The Structure of Glycogen Phosphorylase B with an Alkyldihydropyridine-Dicarboxylic Acid Compound, a Novel and Potent Inhibitor

Zographos, S.E.,Oikonomakos, N.G.,Tsitsanou, K.E.  et al.
(1997)  Structure  5 : 1413 - 1425

DOI: 10.1016/S0969-2126(97)00292-X

Reaction

Chain : A
UniProt : P00489 (PYGM_RABIT)
Reaction: EC: Evidence:
Physiological Direction:
[(1->4)-alpha-D-glucosyl](n) + phosphate = [(1->4)-alpha-D- glucosyl](n-1) + alpha-D-glucose 1-phosphate 2.4.1.1 UniProtKB:P11217
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