Brand  (β version)

PDB ID: 1C80

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Ligands
Code Name Style Show Link
GTP Guanosine-5'-triphosphate PoSSuM
PO4 Phosphate ion PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 1C80   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : REGULATORY COMPLEX OF FRUCTOSE-2,6-BISPHOSPHATASE
Release Data : 2003-06-10
Compound :
mol_id molecule chains
1 FRUCTOSE-2,6-BISPHOSPHATASE A,B
ec: 3.1.3.46
Source :
mol_id organism_scientific organism_common expression_system
1 Rattus norvegicus  (taxid:10116) Norway rat Escherichia coli  (taxid:562)
organ: LIVER
expression_system_plasmid: PET3
Authors : Lee, Y.H., Olson, T.W., McClard, R.W., Witte, J.F., McFarlan, S.C., Banaszak, L.J., Levitt, D.G., Lange, A.J.
Keywords : Rossmann fold, HYDROLASE
Exp. method : X-RAY DIFFRACTION ( 2.2 Å )
Citation :

Reaction Mechanism of Fructose-2,6-bisphosphatase Suggested by the Crystal Structures of a pseudo-Michaelis complex and Metabolite Complexes

Lee, Y.-H.,Olson, T.W.,McClard, R.W.  et al.
To be Published 

Crystal Structure of a Trapped Phosphoenzyme During a Catalytic Reaction

Lee, Y.H.,Olson, T.W.,Ogata, C.M.  et al.
(1997)  Nat.Struct.Biol.  4 : 615 - 618

Reaction

Chain : A, B
UniProt : P07953 (F261_RAT)
Reaction: EC: Evidence:
Physiological Direction:
beta-D-fructose 2,6-bisphosphate + H2O = beta-D-fructose 6- phosphate + phosphate 3.1.3.46 PubMed:2848802
left-to-right
ATP + beta-D-fructose 6-phosphate = ADP + beta-D-fructose 2,6- bisphosphate + H(+) 2.7.1.105 PubMed:2848802
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