Het-PDB Navi2 (PDB: 1C7T)

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Ligands
Code	Name		Link
SO4	Sulfate ion		PoSSuM
NAG	2-acetamido-2-deoxy-beta-D-glucopyranose		PoSSuM
		: Polysaccharide

Non-standard Residues
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Glycosylation
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Download interaction data: 1C7T

Code :

1C7T PDBj RCSB PDB PDBe

Header :

HYDROLASE

Title :

BETA-N-ACETYLHEXOSAMINIDASE MUTANT E540D COMPLEXED WITH DI-N ACETYL-D-GLUCOSAMINE (CHITOBIASE)

Release Data :

2000-09-20

Compound :

mol_id	molecule	chains	synonym
1	BETA-N-ACETYLHEXOSAMINIDASE	A	N-ACETYL-BETA-D-GLUCOSAMINIDASE, CHITOBIASE
	ec: 3.2.1.52 fragment: MATURE PROTEIN, PERIPLASMATIC TARGETING SEQUENCE RESIDUES 1-27 CLEAVED OFF DURING MATURATION mutation: YES other_details: COMPLEXED WITH DINAG

Source :

mol_id	organism_scientific	expression_system
1	Serratia marcescens (taxid:615)	Escherichia coli (taxid:562)
	strain: A9270 expression_system_strain: A5039 expression_system_cellular_location: PERIPLASM expression_system_vector_type: PLASMID expression_system_plasmid: PKK177-3

Authors :

Prag, G., Papanikolau, Y., Tavlas, G., Vorgias, C.E., Petratos, K., Oppenheim, A.B.

Keywords :

GLYCOSYL HYDROLASE, BETA-N-ACETYLHEXOSAMINIDASE, CHITINOLYSIN, A/B(TIM)-BARREL, SITE DIRECTED MUTAGENESIS, PROTON DONOR, CO-CRYSTAL STRUCTURE, HYDROLASE

Exp. method :

X-RAY DIFFRACTION ( 1.90 Å )

Citation :

Structures of chitobiase mutants complexed with the substrate Di-N-acetyl-d-glucosamine: the catalytic role of the conserved acidic pair, aspartate 539 and glutamate 540.

Prag, G.,Papanikolau, Y.,Tavlas, G. et al.
(2000) J.Mol.Biol. 300 : 611 - 617

PubMed: 10884356
DOI: 10.1006/jmbi.2000.3906

Cloning of the Gene Coding for Chitobiase of Serratia Marcescens

Kless, H.,Sitrit, Y.,Chet, I. et al.
(1989) Mol.Gen.Genet. 217 : 471

Bacterial Chitobiase Structure Provides Insight Into Catalytic Mechanism and the Basis of Tay-Sachs Disease

Tews, I.,Perrakis, A.,Oppenheim, A. et al.
(1996) Nat.Struct.Biol. 3 : 638

Chain :

UniProt :

Q54468 (CHB_SERMA)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.	3.2.1.52	-
	-	-

PDB ID: 1C7T

Hetero Atom Contents

Structure summary

Reaction