Het-PDB Navi2 (PDB: 1C5W)

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Ligands
Code	Name		Style	Show	Link
ESI	4-iodobenzo[B]thiophene-2-carboxamidine				PoSSuM
FLC	Citrate anion				PoSSuM

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Download interaction data: 1C5W

Code :

1C5W PDBj RCSB PDB PDBe

Header :

BLOOD CLOTTING

Title :

STRUCTURAL BASIS FOR SELECTIVITY OF A SMALL MOLECULE, S1-BINDING, SUB-MICROMOLAR INHIBITOR OF UROKINASE TYPE PLASMINOGEN ACTIVATOR

Release Data :

2000-12-22

Compound :

mol_id	molecule	chains
1	PROTEIN (UROKINASE-TYPE PLASMINOGEN ACTIVATOR)	A
	ec: 3.4.21.73 fragment: SHORT CHAIN

mol_id	molecule	chains
2	PROTEIN (UROKINASE-TYPE PLASMINOGEN ACTIVATOR)	B
	ec: 3.4.21.73 fragment: CATALYTIC DOMAIN

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Pichia pastoris (taxid:4922)
	expression_system_strain: HISTIDINE DEFICIENT GS115 expression_system_vector_type: PLASMID expression_system_plasmid: PPIC9

mol_id	organism_scientific	organism_common	expression_system
2	Homo sapiens (taxid:9606)	Human	Pichia pastoris (taxid:4922)
	expression_system_strain: HISTIDINE DEFICIENT GS115 expression_system_vector_type: PLASMID expression_system_plasmid: PPIC9

Authors :

Katz, B.A., Mackman, R., Luong, C., Radika, K., Martelli, A., Sprengeler, P.A., Wang, J., Chan, H., Wong, L.

Keywords :

selective, S1 site inhibitor, structure-based drug design, urokinase, trypsin, thrombin, BLOOD CLOTTING

Exp. method :

X-RAY DIFFRACTION ( 1.94 Å )

Citation :

Structural basis for selectivity of a small molecule, S1-binding, submicromolar inhibitor of urokinase-type plasminogen activator.

Katz, B.A.,Mackman, R.,Luong, C. et al.
(2000) Chem.Biol. 7 : 299 - 312

PDB ID: 1C5W