Brand  (β version)

PDB ID: 1C50

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Ligands
Code Name Style Show Link
CHI 5-chloro-1h-indole-2-carboxylic acid [1-(4-fluorobenzyl)-2-(4-hydroxypiperidin-1yl)-2-oxoethyl]amide PoSSuM
PLP Pyridoxal-5'-phosphate PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 1C50   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : IDENTIFICATION AND STRUCTURAL CHARACTERIZATION OF A NOVEL ALLOSTERIC BINDING SITE OF GLYCOGEN PHOSPHORYLASE B
Release Data : 1999-12-23
Compound :
mol_id molecule chains
1 PROTEIN (GLYCOGEN PHOSPHORYLASE) A
ec: 2.4.1.1
Source :
mol_id organism_scientific organism_common
1 Oryctolagus cuniculus  (taxid:9986) Rabbit
tissue: MUSCLE
Authors : Oikonomakos, N.G., Skamnaki, V.T., Tsitsanou, K.E., Gavalas, N.G., Johnson, L.N.
Keywords : GLYCOGEN METABOLISM, GLYCOGEN PHOSPHORYLASE B, INHIBITION, CENTRAL CAVITY, DRUG BINDING SITE, TRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 2.3 Å )
Citation :

A new allosteric site in glycogen phosphorylase b as a target for drug interactions.

Oikonomakos, N.G.,Skamnaki, V.T.,Tsitsanou, K.E.  et al.
(2000)  Structure Fold.Des.  8 : 575 - 584

PubMed: 10873856
DOI: 10.1016/S0969-2126(00)00144-1

Allosteric Inhibition of Glycogen Phosphorylase a by the Potential Antidiabetic Drug 3-Isopropyl 4-(2-Chlorophenyl)-1,4-Dihydro-1-Ethyl-2-Methyl-Pyridine-3,5,6-Tricarboxylate

Oikonomakos, N.G.,Tsitsanou, K.E.,Zographos, S.E.  et al.
(1999)  Protein Sci.  8 : 1930 - 1945

The Structure of Glycogen Phosphorylase b with an Alkyldihydropyridine-Dicarboxylic Acid Compound, A Novel and Potent Inhibitor

Zographos, S.E.,Oikonomakos, N.G.,Tsitsanou, K.E.  et al.
(1997)  Structure  5 : 1413 - 1425

DOI: 10.1016/S0969-2126(97)00292-X

Reaction

Chain : A
UniProt : P00489 (PYGM_RABIT)
Reaction: EC: Evidence:
Physiological Direction:
[(1->4)-alpha-D-glucosyl](n) + phosphate = [(1->4)-alpha-D- glucosyl](n-1) + alpha-D-glucose 1-phosphate 2.4.1.1 UniProtKB:P11217
left-to-right
Cofactor: Evidence: Note:
pyridoxal 5'-phosphate ECO:0000269 | PubMed:7500360
ECO:0000269 | PubMed:8976550
ECO:0007744 | PDB:2PRI
ECO:0007744 | PDB:2SKC
ECO:0007744 | PDB:2SKD
ECO:0007744 | PDB:2SKE
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